Now-a-days, orodispersible drug delivery systems are extensively used to improve bioavailability and patient compliance. Over the past three decades, orodispersible tablets (ODTs) have gained considerable attention as a preferred alternative to conventional tablets and capsules due to better patient compliance, improved solubility and stability profiles. ODTs are solid dosage forms containing m...

Article history: Received on: 13/08/2014 Revised on: 09/09/2014 Accepted on: 15/10/2014 Available online: 27/11/2014 Desloratadine (DS) is a tricyclic antihistaminic, characterized by bitter taste and slight water solubility. The aim of this study is to prepare DS as orally disintegrating tablets (ODT) to mask the bitter taste and improve compliance. Twelve different placebo ODT (F1-F12) were p...

Orally disintegrating tablets (ODTs) have become a rapidly growing area in the pharmaceutical industry during the last decade. Drugs exhibit the advantage of good absorption from the oral mucosa or intending for immediate pharmacological action can be formulated as ODT dosage forms. Rasagiline, a second generation, selective, irreversible inhibitor of mono amine oxidase type B drug, is primaril...

In clinical practice, a thickening solution is frequently coadministered with medicinal tablets to facilitate swallowing by older patients. This study investigated the effect of solutions on reduction in drug dissolution from orally disintegrating (ODTs) testing disintegrant-free ODT, Molded Tablet (MT), and various disintegrant-containing ODTs. After measurement tensile strength test ODTs, was...

Treatment with the atypical antipsychotic drug olanzapine is frequently associated with development of obesity and insulin resistance. Treatment-induced weight gain has been suggested to be the main contributing factor of diminished insulin sensitivity. This study evaluated the effects of short-term treatment with olanzapine on 12h plasma prolactin and cortisol concentrations in healthy men. Th...

Aim. The choice of the qualitative and quantitative composition excipients to provide required mechanical strength disintegration time when developing a pharmaceutical in form orally disintegrating tablets (ODT) based on paracetamol N-acetyl-D-glucosamine. Materials methods. study object was pharmaceutically accepted used development solid dosage forms. To conduct statistical analysis experimen...

Orally Disintegrating Tablets (ODT) have the advantages of both solid dosage form specially the stability and ease of handling and liquid dosage forms including ease of swallowing and pre-gastric absorption. We focused on taste masking and formulation of ranitidine ODT which disintegrates rapidly in the mouth within 60 seconds using super-disintegrants, special polymers, water soluble and even ...

Orally Disintegrating Tablets (ODT) have the advantages of both solid dosage form specially the stability and ease of handling and liquid dosage forms including ease of swallowing and pre-gastric absorption. We focused on taste masking and formulation of ranitidine ODT which disintegrates rapidly in the mouth within 60 seconds using super-disintegrants, special polymers, water soluble and even ...

Since orally disintegrating tablets (ODTs) of tramadol hydrochloride are not available in the market, so an attempt has been taken to formulate and evaluate ODT preparation hydrochloride. In this present work, direct compression was technique used for preparing using superdisintegrants like croscarmellose sodium, sodium starch glycolate crospovidone at different concentrations. Prepared formula...

An antipyretic analgesic drug called paracetamol is used in children to treat mild moderate pain and fever. Orally Disintegrating Tablet (ODT), a medicine that dissolves seconds, was created help who have difficulty swallowing tablets. The purpose of this study determine the effect changes concentration chitosan as disintegrant formulation ODT paracetamol. These tablets are made using wet granu...