The involvement of complement-activation products in promoting tumor growth has not yet been recognized. Here we show that the generation of complement C5a in a tumor microenvironment enhanced tumor growth by suppressing the antitumor CD8+ T cell–mediated response. This suppression was associated with the recruitment of myeloid-derived suppressor cells into tumors and augmentation of their T ce...

Humans are usually exposed to several pesticides simultaneously; consequently, combined actions between pesticides themselves or between pesticides and other chemicals need to be addressed in the risk assessment. Many pesticides are efficient activators of pregnane X receptor (PXR) and/or constitutive androstane receptor (CAR), two major nuclear receptors that are also activated by other substr...

22.12 (2002). 66. Beatch GN, Shinagawa K, Johnson BD et al. RSD1235 selectively prolongs atrial refractoriness and terminates AF in dogs with electrically remodeled atria. S. World. Congr. Pharmacol. 24, Abstract 21.11 (2002). 67. Cardiome drug effective for heart patients. Cardiome Pharma Corp. Press Release

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Methods We sampled bird assemblages in 220 point counts, stratified across three regions and four land-use types. Species richness was examined using accumulation curves and generalized linear mixed-effect models. Compositional and structural changes were analysed with ordination techniques. We used correlations and model selection to identify species traits and environmental variables associat...

As a result of the warming observed at high latitudes, there is significant potential for the balance of ecosystem processes to change, i.e., the balance between carbon sequestration and respiration may be altered, giving rise to the release of soil carbon through elevated ecosystem respiration. Gross ecosystem productivity and ecosystem respiration vary in relation to the pattern of vegetation...