Commercial application of many promising heterocyclic natural products is limited by their natural abundance. While organic synthesis provides access to many natural products, total synthesis of numerous complex molecules is not economically feasible. In recent years, the combination of fermentation and organic synthesis has provided a new route for the production of complex heterocycles that a...

The concept of multicomponent reactions (MCR) [1] has been around in organic chemistry since the very early days. Indeed, the first example known in literature, the Strecker synthesis of α-aminonitriles [2], has been developed into an industrial process for the production of methionine in an annual scale of several hundreds of thousand tons per year. In addition, a lot of syntheses of heterocyc...

There continues to be a need for innovative and inexpensive drugs to treat diseases of the developing world. It is also important to link academic training and research to critical societal needs. Indiana University-Purdue University Indianapolis (IUPUI) is addressing both these concerns by developing a concept called “Distributed Drug Discovery” (D). This Perspective describes how D can harnes...

I s nanoscience the “first full embodiment of post-academic science”? Have many of the traditional core values of publicly funded university science been eroded to the point where they are now “part of a scientific mythology”? And is it “morally bankrupt” to draw a distinction between ‘pure’ and ‘applied’ science? These claims, which were all made in a recent commentary in Nature Nanotechnology...

S. G. Gevorkian, A.E. Allahverdyan, D.S. Gevorgyan, Wen-Jong Ma, Chin-Kun Hu Institute of Physics, Academia Sinica, Nankang, Taipei 11529, Taiwan Yerevan Physics Institute, Alikhanian Brothers St. 2, Yerevan 375036, Armenia 3 Institute of Fine Organic Chemistry, 26 Azatutian ave., Yerevan 0014, Armenia and 4 Graduate Institute of Applied Physics, National Chengchi University, Taipei 11605, Taiw...

S. G. Gevorkian, A.E. Allahverdyan, D.S. Gevorgyan, Chin-Kun Hu Institute of Physics, Academia Sinica, Nankang, Taipei 11529, Taiwan 2 Laboratoire de Physique Statistique et Systèmes Complexes, ISMANS, 44 ave. Bartholdi, 72000 Le Mans, France Yerevan Physics Institute, Alikhanian Brothers St. 2, Yerevan 375036, Armenia and 4 Institute of Fine Organic Chemistry, 26 Azatutian ave., Yerevan 0014, ...

objective too much restriction of dietary proteins can cause severe protein malnutrition,which can occur in adjusting the diet for some kinds of aminoacidopathies, urea cycle disorder and organic academia. this report presents the case of a 1.5-year-old boy with history of phenylketonuria with a three weeks history of erythematous scaly plaques and edema of his extremities; he had a history of ...

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