Orofacial clefts are the commonest congenital structural anomalies of the lip and/or palate. Beyond cosmetic abnormality children often suffer from feeding difficulties, ear infections, hearing loss, speech and language delay, dental problems and multiple craniofacial/dental surgeries. Present study was conducted to assess DNA damage among children with orofacial clefts. One ml of peripheral bl...

Nonsyndromic cleft lip and/or palate (or orofacial cleft, OFC) is a malformation characterized by an incomplete separation between nasal and oral cavities without any associated anomalies. The last point defines the distinction between syndromic and nonsyndromic OFC. Nonsyndromic OFC is one of the most common malformations among live births and is composed of two separate entities: cleft lip wi...

Background Orofacial clefts are among the most common congenital craniofacial malformations and may be associated with other birth defects. However, the proportion and type of additional anomalies vary greatly between studies. This study assessed the prevalence and type of associated congenital malformations in children with orofacial clefts, who attended the largest cleft lip and palate tertia...

OBJECTIVES Cleft lip with or without cleft palate, is the most common serious congenital anomaly that affects the orofacial regions. The management and care of the cleft patient constitutes a substantial proportion of the workload of the Nigerian maxillofacial surgeon and allied specialties. Yet, there are no specific programmes targeted at this group. We believe that the findings of this study...

OBJECTIVES To present descriptive epidemiology of Orofacial Clefts and to determine the association of syndromic forms with antenatal high-risk conditions, preterm birth, and comorbidities among nested-series of cases. METHODS A study of nested-series of cases was conducted. Frequencies of cleft type, associated congenital anomalies, syndromic, non-syndromic and multiple malformation forms, a...

Background and aims: Nowadays, Orofacial clefts are known as the most common orofacial birth defects. Several factors are responsible for problem, such as environmental factors, genetic background, nutritional deficiencies such as Vitamins, zinc, iron, maternal diseases, exposure to teratogenicagents, smoking, drugs, organic solvents. The aim of this study was to evaluate the o...

BACKGROUND While both ionizing and nonionizing radiation are known to impair human reproductive capacity, the role of low-level domestic radiation continues to be an unsettled issue. OBJECTIVES We examined the geostatistical distribution (residential longitude and latitude) of orofacial cleft birth cases adjusted for the underlying population distribution. Furthermore, we examined the cleft b...

OBJECTIVES The authors performed a systematic review and meta-analysis to investigate the possible correlation between ambient air pollution and orofacial cleft anomalies in newborns. MATERIAL AND METHODS A literature search was performed using the PubMed and Google Scholar, using the keywords "air pollution", "cleft lip", "cleft palate", "carbon monoxide", "ozone", "sulfur dioxide", "nitroge...

BACKGROUND A high incidence of orofacial clefts is reported in China, but no data has shown the relation between cleft types and the incidence of other defects so far. The aim of this study is to assess the incidence of congenital heart diseases and other organic defects associated with different types of orofacial clefts. METHODOLOGY AND PRINCIPAL FINDINGS All children with orofacial clefts,...

background and aims: nowadays, orofacial clefts are known as the most common orofacial birth defects. several factors are responsible for problem, such as environmental factors, genetic background, nutritional deficiencies such as vitamins, zinc, iron, maternal diseases, exposure to teratogenicagents, smoking, drugs, organic solvents. the aim of this study was to evaluate the of risk factors fr...