BACKGROUND Cerebral oedema occurs with cerebral malaria, and some clinicians think osmotic diuretics, such as mannitol or urea, may improve outcomes. OBJECTIVES To compare mannitol or urea to placebo or no diuretic for treating children or adults with cerebral malaria. SEARCH STRATEGY We searched the Cochrane Infectious Diseases Group Specialized Register (Issue 4, 2010), CENTRAL (The Cochr...

Mannitol is an osmotic diuretic agent useful in a variety of clinical conditions. This study is based on acid-base and electrolyte changes seen after the intravenous infusion of hypertonic mannitol for the prevention of cerebral edema. The study subjects were divided into 3 groups: for group A, an amount of 300-900 mL 15% mannitol was intravenously infused over the period of 60 to 90 minutes; f...

OBJECTIVES The aims of this study were to investigate the feasibility of isosorbide delivery into perilymph through the round window membrane (RWM), and to compare the intracochlear isosorbide concentration in perilymph after oral administration (PO) versus that after round window perfusion (RWP). METHODS Sixteen male guinea pigs (32 ears) were used. Isosorbide, an osmotic diuretic, was admin...

Oral urea has been used in the past to treat various diseases like gastric ulcers, liver metastases, sickle cell disease, heart failure, brain oedema, glaucoma, Meniere disease, etc. We have demonstrated for years, the efficacy of urea to treat euvolemic (SIADH) or hypervolemic hyponatremia. We briefly describe the indications of urea use in symptomatic and paucisymptomatic hyponatremic patient...

OTT, C. E., L. G. NAVAR, AND A. C. GUYTON. Pressures in static and dynamic states from capsules implanted in the kidney. Am. J. Physiol. 22 l(2) : 394-400. 197 1 .-Renal interstitial fluid pressure was measured in 35 unanesthetized dogs from perforated capsules implanted in the kidney. Pressure measurements were made from a small catheter run from the interior of the capsule to the exterior of ...

this is a letter to editor.There is growing interest in the health benefits of botanical diuretics. (1-2) ‎Avicenna (980-1037 AD), the foremost Iranian physician,‎‏ ‏introduced ‎numerous herbs as diuretics in his renowned book of Canon of Medicine. (3)‎Avicenna and his followers have recommended herbal diuretics for most ‎ailments accompanied by fluid superabundance like lassitude, oedema, and ...

this is a letter to editor.There is growing interest in the health benefits of botanical diuretics. (1-2) ‎Avicenna (980-1037 AD), the foremost Iranian physician,‎‏ ‏introduced ‎numerous herbs as diuretics in his renowned book of Canon of Medicine. (3)‎Avicenna and his followers have recommended herbal diuretics for most ‎ailments accompanied by fluid superabundance like lassitude, oedema, and ...

Hyponatraemia is a common biochemical abnormality, occurring in about 15% of hospital inpatients. It is often associated with severe illness and relatively poor outcome. Pathophysiologically, hyponatraemia may be spurious, dilutional, depletional or redistributional. Particularly difficult causes and concepts of hyponatraemia are the syndrome of inappropriate antidiuresis and the sick cell synd...