The role of estrogen signaling in regulating prostate tumorigenesis is relatively underexplored. Although, an increasing body of evidence has linked estrogen receptor beta (ERß) to prostate cancer, the function of estrogen receptor alpha (ERα) in prostate cancer is not very well studied. We have discovered a novel role of ERα in the pathogenesis of prostate tumors. Here, we show that prostate c...

With rising incidence of breast carcinoma in Asian population, staging workup remains a crucial entity diseasemanagement and outcome. Bone scintigraphy for detection osteoblastic metastasis has remained convenient choice.However, the presence underlying lytic bony lesions sensitivity 99mTc-MDP bone scan is questionable when comparedto 18F-FDG PET-CT scan. We present case that showed better pick...

W hen cancer metastasizes to distant sites, it essentially forms an army of occupation. Just as the presence of an army of occupation alters the behavior of the preexisting resident population, the resident host cells react in a variety of ways to the presence of the metastatic cancer cells. In the majority of cases, they increase their resorptive or destructive capacity, and the result is an o...

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The reciprocal interaction between cancer cells and the tissue-specific stroma is critical for primary and metastatic tumor growth progression. Prostate cancer cells colonize preferentially bone (osteotropism), where they alter the physiological balance between osteoblast-mediated bone formation and osteoclast-mediated bone resorption, and elicit prevalently an osteoblastic response (osteoinduc...

Introduction: Osteoblastic bone metastasis is the main cause of morbidity and mortality from androgen-independent prostate cancer. Currently there are very few models that reflect the osteoblastic phenotype of prostate cancer. Recently however, a clinically relevant xenograft model of osteoblastic bone metastases was established from an androgen-independent prostate cancer patient. This model d...

Animal Prostate Carcinoma Models: Limited Potential for Vertebral Metastasis p. 151 A Model for Studies on Human Prostatic Carcinoma p. 159 Studies on the Pathogenesis of Osteoblastic Metastases by Prostate Cancer p. 165 Analysis of Bone Metastasis of Prostatic Adenocarcinoma in 137 Autopsy Cases p. 173 Nucleolar Organizer Regions in Prostate Cancer p. 183 Flow Cytometric Analysis of Prostatic ...

Abstract Prostate cancer is one of the most common cancers affecting men. Bone scan part staging modality commonly used to evaluate bone metastasis. A with diffused increased skeletal tracer uptake relative soft tissue, combined faint renal activity known as a superscan. However, primary concern are false negatives associated scans, where diffuse metastasis indistinguishable on superscans. In t...

Osteosarcoma (OS) is a rare bone neoplasm that affects mainly adolescents. It is associated with poor prognosis in case of metastases formation. The search for metastasis predicting markers is therefore imperative to optimize treatment strategies for patients at risk and important for the search of new drugs for the treatment of this devastating disease. Here, we have analyzed by microarray the...