نتایج جستجو برای: osteoclast
تعداد نتایج: 6026 فیلتر نتایج به سال:
objective(s): to determine the effect of different doses of caffeine on orthodontic tooth movement (otm) in rats. materials and methods: forty male 250-300 g sprague-dawley rats were randomly divided into four groups of ten animals each and received 0 (control), 1 g/l, 2 g/l and 3 g/l caffeine in tap water for 3 days. orthodontic appliances were ligated between the maxillary first molars and in...
An unbalanced diet can have adverse effects on health. Long chain polyunsaturated fatty acids (LCPUFAs) have been the focus of research owing to their necessity of inclusion in a healthy diet. However, the effects of LCPUFAs on human osteoclast formation and function have not been explored before. A human CD14+ monocyte differentiation model was used to elucidate the effects of an ω-3 LCPUFA, d...
Melphalan is a cytotoxic chemotherapy used to treat patients with multiple myeloma (MM). Bone resorption by osteoclasts, by remodeling the bone surface, can reactivate dormant MM cells held in the endosteal niche to promote tumor development. Dormant MM cells can be reactivated after melphalan treatment; however, it is unclear whether melphalan treatment increases osteoclast formation to modify...
We reported that interleukin (IL) 6 alone cannot induce osteoclast formation in cocultures of mouse bone marrow and osteoblastic cells, but soluble IL-6 receptor (IL-6R) strikingly triggered osteoclast formation induced by IL-6. In this study, we examined the mechanism of osteoclast formation by IL-6 and related cytokines through the interaction between osteoblastic cells and osteoclast progeni...
BACKGROUND Osteoclasts, cells responsible for bone resorption, contribute to the development of degenerative, metabolic and neoplastic bone diseases, which are often characterized by persistent changes in bone microenvironment. We aimed to investigate the dynamics of osteoclast formation and death in cultures that considerably exceeded the length of standard protocol and to design a mathematica...
A receptor that mediates osteoprotegerin ligand (OPGL)-induced osteoclast differentiation and activation has been identified via genomic analysis of a primary osteoclast precursor cell cDNA library and is identical to the tumor necrosis factor receptor (TNFR) family member RANK. The RANK mRNA was highly expressed by isolated bone marrow-derived osteoclast progenitors and by mature osteoclasts i...
Curcumin is known could inhibit the activation of NF-kB, which is important in osteoclast differentiation and activation. The aims of this research were to conduct the effect of curcumin and Pentagamavunon-0 or PGV-0 [2,5-bis-(4’-hydroxy-3’methoxybenzylidene)-cyclopentanone], on osteoclast differentiation and apoptosis. Osteoclast differentiation was carried out using Osteoclast Differentiation...
introduction: maxillary osteomyelitis is a rare phenomenon. if it occurs, evaluation for underlying disease especially osteopetrosis must be considered. osteomyelitis occurs as a complication in 10% of the cases of osteopetrosis. case report: this is a case report of maxillary osteomyelitis presented in a 15-year old boy with osteopetrosis. in this case, the disease represented mainly with fac...
Osteoclasts are unique cells responsible for the resorption of bone matrix. MicroRNAs (miRNAs) are involved in the regulation of a wide range of physiological processes. Here, we examined the role of miR-26a in RANKL-induced osteoclastogenesis. The expression of miR-26a was up-regulated by RANKL at the late stage of osteoclastogenesis. Ectopic expression of an miR-26a mimic in osteoclast precur...
It has been shown that high vitamin A intake is associated with bone fragility and fractures in both animals and humans. However, the mechanism by which vitamin A affects bones is unclear. In the present study, the direct effects of retinoic acid (RA) on human and murine osteoclastogenesis were evaluated using cultured peripheral blood CD14(+) monocytes and RAW264.7 cells. Both the activity of ...
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