Osteopoikilosis or spotted bone disease is a rare dysplasia of unknown etiology. It characterized by an abnormality in maturation process and often found incidentally on radiologic examination. This disease, which has autosomal dominant inheritance, numerous, annular oval, sclerotic lesions with regular borders. Although it frequently asymptomatic, rarely polyarthralgia joint swelling may occur...

Osteopoikilosis is an autosomal dominant bone disorder characterized by symmetric multiple osteosclerotic lesions throughout the axial and appendicular skeleton. Pathogenic variants in the LEMD3 have been identified as the cause of osteopoikilosis. LEMD3 encodes an inner nuclear membrane protein that interacts with bone morphogenetic protein (BMP) and transforming growth factor (TGF)-β pathways...

Background: Osteopoikilosis is a rare benign osteosclerotic dysplasia and occurs in 1/50,000 people. inherited an autosomal dominant associated with several clinical manifestations. Currently, there no agreement on diagnosing osteopoikilosis. In this case report, we describe 24-year-old female patient complaining of lump pain the sole right foot. Case presentation: A 24 years complained painful...

Osteopoikilosis (OP) is a very rare benign sclerosing bony dysplasia with an autosomal dominant inheritance. We describe the morphology of an osteopoikilosis male patient, associated with severe pain on wrist and hand joints, report on the relative literature and focus on clinical significance, due to mimicking capability of other more severe conditions such as bone metastases.

Osteopoikilia, also referred to as osteopoikilosis, is an asymptomatic osteosclerosing dysplasia, of non-specific etiology first described by Albers-Shonberg.1 We report the case of a 49-year-old patient in whom osteopoikilosis affected both femurs, the pelvis and spine. To the best of our knowledge, spinal localization was exceptional.2 The diagnosis was made by chance when reviewing lumbar sp...

Spotted bones associated with benign conditions can have a very typical radiographic appearance and distribution; however, ambiguity in this appearance or a history of malignant disease can lead to diagnostic uncertainty and the need for further investigation. This clinical primer will focus on one characteristic benign condition, osteopoikilosis, its relevant differential diagnosis and workup....

Osteopoikilosis is a benign but rare condition characterized by bone islands throughout the osseous tissue, which could be easily confused with bone metastasis. We present a case of a 37-year-old man presented to orthopedic outpatient clinic with right hip pain for 2 weeks. There were multiple, small punctate lesions scattered throughout the skeleton on radiograph. Subsequent Tc-99m methylene d...

osteopoikilosis is a rare benign osteosclerotic bone disorder that may be misdiagnosed as skeletal metastases. here we describe a case of coincidental breast cancer and osteopoikilosis mimicking skeletal metastases. a 41-year-old woman underwent right modified radical mastectomy in april 2007. twenty-eight months after initial treatment, the patient complained of bilateral knee and foot pain. p...