PURPOSE Osteopontin is a secreted cytokine that binds to the cell surface CD44v6 receptor. We studied osteopontin and CD44v6 expression in laryngeal squamous cell carcinomas and correlated osteopontin expression levels with clinicopathologic tumor features. EXPERIMENTAL DESIGN We used immunohistochemistry, immunoblotting, and reverse transcription-PCR to study osteopontin expression in 58 lar...

BACKGROUND T cells in peripheral blood reflect the systemic inflammatory response in patients with heart failure (HF). In a rat model of HF, osteopontin is dramatically increased in the left ventricular myocardium, so the association between osteopontin and HF was examined in the present study. METHODS AND RESULTS Peripheral blood was collected from 93 patients with heart disease and 38 contr...

OBJECTIVE Osteopontin is used as a biomarker for measuring the severity of atherosclerosis, but the role of osteopontin in the pathogenesis of atherosclerosis is not clear. METHODS The distribution and determinants of osteopontin were studied in a randomized cohort of 1,817 young adults (aged 30–45 years) without clinical symptoms of atherosclerosis. RESULTS The mean ± SD osteopontin concen...

Over recent years several non-collagenous matrix proteins of bone have been isolated and characterized. One of these proteins, osteopontin, has been shown to be synthesized by osteoblasts and deposited in the bone matrix where it is thought to bind to hydroxyapatite. However much of the functional evidence is circumstantial, and the precise function of osteopontin has not been fully elucidated....

PURPOSE To examine whether tissues of human capsular opacification and subcapsular cataract contain osteopontin, an adhesive matrix protein, and whether mouse lens epithelium expresses osteopontin after injury. METHODS An immunohistochemical examination was conducted to determine whether matrices in human postoperative capsular specimens and anterior subcapsular cataract contain osteopontin. ...

background: meningioma is among the most common slow growing central nervous neoplasms, which recurs locally despite the benign histologic features. the aim of this study was to evaluate osteopontin and ki67 expressions in different histologic grades of meningioma in a group of iranian people. methods: in this cross-sectional study, first, the paraffin blocks with the definite pathological diag...

down-regulation of osteopontin and breast tumour progression in vivo is highly interesting [1]. Recent studies indicate a close association between not only breast cancer and osteopontin but other systemic malignancies as well. Studies over the past few years have especially shown a strong relationship between osteopontin expression and oral carcinogenesis. For instance, Devoll et al. in a rece...

UNLABELLED Osteopontin expression in human crescentic glomerulonephritis. BACKGROUND Osteopontin is a molecule with diverse biological functions, including cell adhesion, migration, and signaling. The expression of osteopontin has been demonstrated in a number of models of renal injury in association with accumulations of monocyte/macrophages, including recent reports of osteopontin expressio...

PURPOSE This was a pilot study conducted to examine the expression of osteopontin in uveal melanoma and to determine whether serum osteopontin can be used in detecting metastatic uveal melanoma. METHODS Osteopontin mRNA was measured in three uveal melanoma cell lines of various invasive potential by real-time PCR. Tissue sections of primary and metastatic uveal melanomas were stained for oste...

Objective: This study aimed to assess osteopontin expression following immunohistochemical staining of odontogenic cysts and tumors. Methods: A systematic review was conducted based on PRISMA Statement. The literature search carried out through PubMed, Scopus, Science Direct databases, covering all the articles published up October 2021, using a combination key terms ‘osteopontin’, ‘odontogenic...