BACKGROUND: Formation of tumour mass is one symptom osteosarcoma development. Caffeic acid has been known to provide effective treatment but less side effect for some cancer therapy. Studies reported that caffeic might promote apoptosis in MG-63 cells, however, the preventing formation not well elucidated, especially cells-induced nude mice vivo.METHODS: cells were pre-treated with 0, 1, or 10 ...

Osteosarcoma refers to a bone tumor and the term was introduced by John Abernathy in 1804 referring fleshy growth [1]. In 2009, Ottaviane G. et al reported that osteosarcoma is an aggressive malignancy arises from primitive transformed cells of mesenchymal origin produces malignant osteoid, which are most common representation primary cancer [2,3].

osteosarcoma is a primary malignant tumor of bone, which can involve jaws. this article reviews osteosarcoma of the jaws referred to the department of oral pathology, dental faculty of tehran university of medical sicences and pathology department of cancer institiute in imam khomeini hospital during 30 years from 1349 to 1378 and also reviews jaw osteosarcoma in english literature. the purpose...

Osteosarcoma is a common childhood bone cancer with a poor survival rate. Osteosarcoma cancer stem cells (CSCs) contribute to the recurrence, drug resistance and metastasis of this disease. Previous evidence suggested that cancer cells are able to spontaneously turn into CSCs, thus it is crucial to simultaneously target osteosarcoma cells and CSCs. Our previous studies have demonstrated that sa...

Monocyte chemotactic protein‑1 (MCP‑1/CCL2) is an important immune factor, which may be important in cancer progression by promoting proliferation, invasion, metastasis and the tumor microenvironment. Previous studies have demonstrated that CCL2 affects the proliferation of osteosarcoma cells via the RANKL signaling pathway. However, the underlying mechanisms remain to be elucidated. To investi...

Abstract NK cells-based cancer therapy combined with chemotherapeutic drugs for the treatment of tumors can enhance immunosensitivity cells, increase expression cell receptors, and eventually boost killing effect cells on cells. Selenium (Se) different chemical structures be metabolized into selenoproteins to regulate tumor immune cells’ fate functions. Herein, we found that, functionalized Se ...

Abstract Osteosarcoma is the most common primary malignant bone tumor; main treatment method surgery and adjuvant chemotherapy, with a 5-year survival rate of less than 20% for metastatic patients. Schisandrin B abundant active ingredient found in fruit Schisandra chinensis (Turcz.) Baill., Schisandraceae, which has document properties such as liver protection, antioxidant, anti-inflammatory, a...

Osteosarcoma is a common cancer type among the youth population and usually develops in growing bones. Approximately twenty percent of osteosarcoma cases show tendency to metastases patients with have low survival rate after treatment. RANK/RANKL/OPG key regulator triad bone remodeling play critical roles tumourigenesis osteosarcoma. Anti-proliferative activity gambogic acid was determined Saos...

Purpose: To investigate the effect of emodin on osteosarcoma cell proliferation and apoptosis.
 Methods: The ability was determined by CCK-8, apoptosis level cycle were via flow cytometry. Honechst staining used to determine ratio nuclear pyknosis, Western blotting expression AKT, p-AKT caspase-3 precursor protein in each group cells.
 Results: Emodin significantly inhibited MG-63 pro...

MiR-429 functions as a tumor suppressor and has been observed in multiple types of cancer, but the effects and mechanisms of miR-429 in osteosarcoma are poorly understood. This study is performed to evaluate the functions of miR-429 in the progression of osteosarcoma. Firstly, the miR-429 expression in osteosarcoma tissues and osteosarcoma cells was detected using real time PCR, and the relatio...