Hyperparathyroidism is an endocrine abnormality that frequently causes diffuse osteopenia in the bones. Osteosclerosis is a rare phenomenon in adults with primary hyperparathyroidism since the usual skeletal manifestation is generalized osteopenia. We describe a patient with generalized osteosclerosis in the jaws and skull in association with primary hyperparathyroidism, while the other skeleta...

Non-pathological densification (osteosclerosis) and swelling (pachyostosis) of bones are the main modifications affecting the skeleton of land vertebrates (tetrapods) that returned to water. However, a precise temporal calibration of the acquisition of such adaptations is still wanting. Here, we assess the timing of such acquisition using the aquatic sloth Thalassocnus, from the Neogene of the ...

Objectives: This study was performed to investigate the prevalence of idiopathic osteosclerosis on cone beam computed tomography (CBCT) images of patients. Methods: In this descriptive, cross-sectional study, 240 CBCT scans of patients (125 women, 115 men) referred to a private oral and maxillofacial radiology clinic in Tehran in 2013 were selected and evaluated. Presence of idiopathic osteosc...

Fig. 1. X-ray of left forearm and hand showing osteosclerosis, ‘bone in bone’ appearance of shaft, fracture both bones, fraying and early cupping of metaphysis and widening of ‘physis’, the growth plate and absence of carpal bones. pathological fractures with ‘bone in bone’ appearance, increase in medullary density, defective metaphyseal remodeling with fraying and early cupping and widening of...

Osteosclerosis of the subchondral bone was measured by densitometer on plain radiographs in 55 medial compartmental osteoarthritic knees of 40 patients who were treated with high tibial valgus osteotomy for correction of varus deformity. The ratio of the osteosclerosis value of the medial side of the knee to that of the lateral side (Medial/Lateral ratio) was calculated and used as a parameter....

We have previously shown that mice induced to overexpress thrombopoietin (TPO) by retroviral-mediated gene transfer into bone marrow (BM) cells develop myelofibrosis and osteosclerosis. It was speculated that these effects were secondary to TPO, resulting from high levels of megakaryocytes and platelets. Also, it was proposed that these mice represent a model for myelofibrosis and osteosclerosi...

In multiple myeloma the typical bone lesions are usually purely osteolytic and the presence of any osteosclerosis suggests that the diagnosis should be reconsidered. There have now been reports of forty-nine patients with myeloma with osteosclerotic deposits in whom radiotherapy could not be implicated as a cause (Kr , Wiedermann, Vykydal and Soyka 1967; Evison and Evans 1967; Osuntokun, Akinku...