نتایج جستجو برای: osx

تعداد نتایج: 263  

Journal: :Physiological genomics 2013
Shaohong Cheng Weirong Xing Xin Zhou Subburaman Mohan

Osterix (Osx) is essential for both intramembranous or endochondral bone formation. Osteoblast-specific ablation of Osx using Col1α1-Cre resulted in osteopenia, because of impaired osteoblast differentiation in adult mice. Since Osx is also known to be expressed in chondrocytes, we evaluated the role of Osx expressed in chondrocytes by examining the skeletal phenotype of mice with conditional d...

2006
O ’ Keefe

INTRODUCTION: Insight into elucidating the transcriptional regulatory mechanisms underlying the successive events that mediate endochondral ossification is important in understanding possible mechanism of disease as well as cures to severe diseases ranging from skeletal dysplasia to fracture nonunion. The zinc finger-containing transcription factor Osterix (Osx) was demonstrated to be a key med...

Journal: :Cell 2002
Kazuhisa Nakashima Xin Zhou Gary Kunkel Zhaoping Zhang Jian Min Deng Richard R. Behringer Benoit de Crombrugghe

We have identified a novel zinc finger-containing transcription factor, called Osterix (Osx), that is specifically expressed in all developing bones. In Osx null mice, no bone formation occurs. In endochondral skeletal elements of Osx null mice, mesenchymal cells, together with osteoclasts and blood vessels, invade the mineralized cartilage matrix. However, the mesenchymal cells do not deposit ...

Journal: :Molecular cancer research : MCR 2008
Ying Cao Shu-Fang Jia Geetika Chakravarty Benoit de Crombrugghe Eugenie S Kleinerman

K7M2 mouse osteosarcoma cells form lytic tumors and are deficient in osterix (Osx), a zinc finger-containing transcription factor required for osteoblast differentiation and bone formation. Our previous studies showed that replacement of Osx suppresses lytic bone destruction. Cytokines, including interleukin (IL)-1alpha, IL-6, IL-11, and prostaglandin E2, have been shown to stimulate osteoclast...

2011
Xianghuai Lu George R Beck Linda C Gilbert Corinne E Camalier Nicholas W Bateman Brian L Hood Thomas P Conrads Michael J Kern Shaojin You Hong Chen Mark S Nanes

Tumor necrosis factor α (TNF-α) promotes bone loss and inhibits bone formation. Osterix (Osx, SP7) is a transcription factor required for osteoblast (OB) differentiation because deletion results in a cartilaginous skeleton. We previously described a TNF suppressor element in the Osx promoter that was used to isolate nuclear proteins mediating TNF inhibition of OB differentiation. Nuclear extrac...

2015
Zhengguo Cao Rubing Liu Hua Zhang Haiqing Liao Yufeng Zhang Robert J. Hinton Jian Q. Feng

Osterix (Osx), a transcriptional factor essential for osteogenesis, is also critical for in vivo cellular cementum formation. However, the molecular mechanism by which Osx regulates cementoblasts is largely unknown. In this study, we initially demonstrated that overexpression of Osx in a cementoblast cell line upregulated the expression of markers vital to cementogenesis such as osteopontin (OP...

Journal: :Physiological genomics 2011
Weirong Xing Sheila Pourteymoor Subburaman Mohan

Mouse genetic studies reveal that ascorbic acid (AA) is essential for osteoblast (OB) differentiation and that osterix (Osx) was a key downstream target of AA action in OBs. To determine the molecular pathways for AA regulation of Osx expression, we evaluated if AA regulates Osx expression by regulating production and/or actions of local growth factors and extracellular matrix (ECM) proteins. I...

2010
Chi Zhang

Bone formation is a complex developmental process involving the differentiation of mesenchymal stem cells to osteoblasts. Osteoblast differentiation occurs through a multi-step molecular pathway regulated by different transcription factors and signaling proteins. Osx (also known as Sp7) is the only osteoblast-specific transcriptional factor identified so far which is required for osteoblast dif...

2015
BO LIU SONG WU LIHUA HAN CHAOYUE ZHANG

Both β-catenin (β-cat) and osterix (OSX) are known to be essential for embryonic and postnatal osteoblast differentiation and bone growth. In the present study, we explored the crosstalk between β-cat signaling and OSX, and assessed its effect on the osteoblastogenic differentiation of human pre-osteoblastic cells (MG-63) and bone marrow stromal cells (HS-27A). In the HS-27A and MG-63 cells, th...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2010
Xin Zhou Zhaoping Zhang Jian Q Feng Vladmir M Dusevich Krishna Sinha Hua Zhang Bryant G Darnay Benoit de Crombrugghe

The transcription factor Osterix (Osx) is required for osteoblast differentiation and bone formation during embryonic development, but it is not known whether Osx has an essential function in postnatal bone growth and in bone homeostasis. Conditional deletion of Osx at several time points postnatally revealed that Osx was essential for osteoblast differentiation and new bone formation in growin...

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