OBJECTIVES/HYPOTHESIS The genetic factors leading to a predisposition to otitis media are not well understood. The objective of the current study was to develop a tag-single nucleotide polymorphism (SNP) panel to determine if there is an association between candidate gene polymorphisms and the development of chronic otitis media with effusion. STUDY DESIGN A 1:1 case/control design of 100 cas...

Otitis media (OM) is an infection localized in the middle ear: mastoid, middle ear cavity, Eustachian tube. The classification of OM includes otitis media with effusion, otitis media without effusion, and chronic otitis media. A rare complication of chronic otitis is cholesterol granuloma of the petrous apex. It may develop in any aerated portion of the temporal bone but most commonly develops ...

This report presents the results of the clinical observation of 96 children under ten years of age with acute otitis media (107 ears) who visited our out-patient clinic from May 1986 to August 1987. The patients were classified into the following three groups according to clinical course: Group 1: 25 cases (26.0%) in which acute inflammatory findings rapidly disappeared and otitis media was cur...

AIM Auditory tube dysfunction is one of the aetiological causes of otitis media. Studies suggest a correlation between otitis media with effusion and dental malocclusion. Our goal was to determine any correlation between dental malocclusion and otitis media with effusion in children with chronic upper airway obstruction due to tonsil and adenoid enlargement. MATERIALS AND METHODS This prospec...

Objective: To investigate the expression of receptor for advanced glycation endproducts (RAGE) in adenoid hypertrophy in children and the change in the level of soluble receptor for advanced glycation endproducts (sRAGE) in tympanic effusion. Methods: Fifteen adenoidal specimens were collected from patients with adenoidal hypertrophy and secretory otitis media and patients with simple adenoidal...

OBJECTIVES Children under 2 years of age with acute otitis media are known to have a relatively poor prognosis. The objective of this study was to assess whether known determinants for recurrent acute otitis media and persistent middle ear effusion after an episode of acute otitis media during childhood also apply to children under 2 years. METHODS STUDY DESIGN prospective study of 210 chi...

BACKGROUND Studies concerning spectral gradient acoustic reflectometry (SG-AR) have analyzed middle ear effusion only as 1 entity. The usefulness of SG-AR to detect specific otoscopic diagnoses of otitis media in young children is unknown. METHODS Among 515 children aged 6-35 months, we compared SG-AR with pneumatic otoscopy and evaluated the proportions of 5 manufacturer-recommended SG-AR le...

Acute otitis media and otitis media with effusion are common childhood disorders, a source of significant morbidity, and a leading cause of antibiotic prescription in primary health care. Although effective treatments are available, some shortcomings remain, and thus better treatments would be welcome. Recent discoveries within the field of otitis media research relating to its etiology and pat...

OBJECTIVE To determine whether there is an association between otitis media with effusion and laryngopharyngeal reflux in children. MATERIALS AND METHODS This study included 31 children with otitis media with effusion. The pepsinogen level in the middle ear fluid of all patients was measured by sandwich enzyme-linked immunosorbent assay. Each patient's middle ear fluid was investigated for He...

the middle ear is the most prevalent disease of childhood. The other areas of the temporal bone which can be contiguous with the middle ear, including the mastoid, petrousus apex and perilabyrinthine air cells, may also be involved. Otitis media can be further divided into acute otitis media (AOM) without effusion, otitis media with effusion (OME), chronic suppurative otitis media (COM) with or...