Contemporary publications on possible pharmaceutical treatment of ototoxic effect aminoglycosides have been analyzed. In this respect, substances with the antioxidant seem to be most promising. Their use in therapeutic doses is not accompanied by adverse reactions, and they do interfere antibacterial anti-tuberculosis drugs. Currently, mechanisms otoprotective action various antioxidants are be...

ÐThe ototoxic damage that drugs such as neomycin, kanamycin, colistin, cisplatin, transplatin and carboplatin cause on outer and inner hair cells in postnatal day 3 rat cochlear explants was investigated. Phalloidin± ̄uorescein conjugate-stained stereocilia bundles of sensory hair cells were quanti®ed by video image analysis as a measurement of ototoxic e€ect. The video image quanti®cation syste...

BACKGROUND AND PURPOSE To report on the incidence and relative risk of tinnitus onset from a variety of drug therapies known to be ototoxic. Two main questions were asked: (1) What is the prevalence and incidence of tinnitus among patients treated with cisplatin, carboplatin, or ototoxic antibiotic therapies? (2) Do commonly reported treatment or subject factors confound or modify the incidence...

A leading cause of preventable sensorineural hearing loss is therapeutic treatment with medications that are toxic to inner ear tissues, including certain drugs used to fight cancer and life-threatening infectious diseases. Ototoxic-induced hearing loss typically begins in the high frequencies and progresses to lower frequencies as drug administration continues (Campbell & Durrant, 1993; Campbe...

Drug-induced ototoxicity has been known for centuries. Already in the seventeenth century, hearing loss was described to be a side effect of quinine. The postWorld War II pharmaceutical industry boomed with the production of aminoglycoside antibiotics followed by diuretics and cytostatic drugs. Wide-spread and long-term usage of these medications brought the knowledge about their unwanted ototo...

one of the complications of end-stage renal disease (esrd) is sensorineural hearing loss (snhl). despite large number of studies on adults esrd patients, there are only a few reported surveys regarding snhl in children. to determine the prevalence of snhl in children with esrd and its relationship with sex of patients, presence of hypertension, history of ototoxic drugs administration and durat...