Background: Oxcarbazepine is a widely used novel antiepileptic drug . In vitro electrophysiology studies indicate that oxcarbazepine produced blocked of voltagesensitive sodium channels , resulting in stabilization of hyper exited neural membranes , inhibition of propagation of synaptic impulses . In this research the effect of oxcarbazepine has been studied on the amount LH , FSH , testosteron...

Oxcarbazepine is a second-generation antiepileptic drug that is used to treat partial seizures. Although it has been increasingly used in pregnant women, its fetal safety has not been fully validated. We describe a 12-hour-old neonate who developed neonatal abstinence syndrome (NAS) after intrauterine exposure to oxcarbazepine. The neonate was born via cesarean section to a mother who took oxca...

Oxcarbazepine recently gained a licence in the UK and USA. The purpose of this article is to review the pharmacology and therapeutics of oxcarbazepine for those prescribers unfamiliar with this interesting new antiepileptic drug1–3. Although only newly licensed in the UK and USA, oxcarbazepine has in fact been in routine clinical use in Denmark and other countries for up to 10 years, and experi...

The antiepileptic efficacy and tolerability of oxcarbazepine, used both as monotherapy and adjunctive therapy, were observed for 1 year in 202 adult patients, aged 17-83 years, with newly diagnosed or refractory partial epilepsy in clinical practice in Italy. At first observation, the seizure free rate was 72.2% in newly diagnosed patients given monotherapy, 40% in patients in whom oxcarbazepin...

BACKGROUND Peripheral neuropathy is one most common, limiting and invalidating neurological symptom in subjects with hepatitis C virus and mixed cryoglobulinemia. Notably, the medical therapy proposed to eradicate HCV, can frequently exacerbate the painful neuropathy. Therefore, neuropathy therapies are insufficient and inadequate, and comprise immunosuppressive drugs, such as steroid or cyclos...

CONTEXT AND OBJECTIVE It has been estimated that 50 million people worldwide suffer from epilepsy and around 30% will not achieve adequate control over the disease. The aim was to evaluate the effectiveness of oxcarbazepine for refractory partial or generalized epilepsy. METHODS Systematic review. A search was conducted in the PubMed, Lilacs, EMBASE and CENTRAL databases. Studies were analyze...

We report two cases with complex partial and secondarily generalized seizures, both on oxcarbazepine and vigabatrin, with additional lamotrigine in one case. Both died in a manner resembling SUDEP, i.e. suddenly, unexpectedly, probably following a seizure with pulmonary oedema at autopsy. Both had SIADH. A number of drugs may cause SIADH, among them carbamazepine and oxcarbazepine. A search for...

BACKGROUND AND PURPOSE Antiepileptic drug (AED)-associated cutaneous adverse drug reactions can lead to the discontinuation of medications. The aim of this study was to determine the long-term efficacy and safety of performing desensitization to oxcarbazepine. METHODS This study involved 20 patients who exhibited cutaneous adverse drug reactions associated with oxcarbazepine use between July ...

Oxcarbazepine is a representative molecule for a new class of anticonvulsant drugs that can treat alcohol dependence in addition to other disorders. Interestingly, the central mechanism of action in oxcarbazepine is very similar to ethanol, suggesting that these two agents may interact and cause enhanced effects in the central nervous system. In this study, we used a pharmaco-EEG method to exam...

Abstract The pursuit of ideal multi‐modal analgesic strategies remains ongoing, though the use select antiepileptic drugs as adjunctive analgesics to opioids has been previously studied and postulated have varying degrees success. objective this review was determine efficacy safety in an update a published Cochrane on subject 2013. A comprehensive literature conducted using PubMed, MEDLINE, Sco...