A series of erythromycin A 9-O-substituted oxime ether derivatives have been synthesized and evaluated for antibacterial activity against Mycobacterium avium complex (MAC) and Staphylococcus aureus. These compounds possessed stronger in vitro activity against MAC including macrolide-resistant strains than clarithromycin (2), although in vitro antibacterial activities of these compounds were les...

Peptide-based complex biomacromolecules are now optimally assembled by sequential ligation of unprotected peptide segments. However, this approach is still limited by the laborious chromatographic purification and handling steps needed for multiple successive chemoselective couplings, which leads to loss of material. An efficient alternative is solid phase chemical ligation (SPCL) initially dev...

In the mol-ecule of the title compound, C(17)H(18)N(2)O(2), the dihedral angle between the aromatic rings is 74.26 (3)°. The oxime units are oriented at dihedral angles of 7.66 (3) and 33.06 (3)° with respect to the adjacent rings, and they have E configurations about the C=N bonds.

The aim of this study was to report the synthesis of biologically active compounds; 7-(2'-aminoethoxyimino)-cholest-5-ene (4), a steroidal oxime-ether and its derivatives (5, 6) via a facile microwave assisted solvent free reaction methodology. This new synthetic, eco-friendly, sustainable protocol resulted in a remarkable improvement in the synthetic efficiency (85-93 % yield) and high purity ...

C-glucosyl, mannosyl and galactosyl 2-iodopropane, readily obtained from the corresponding C-glycosyl ketones, were coupled with (+)- or (-)-camphorsultam glyoxylic oxime ether with diastereoselectivity ranging from 70:30 to 80:20. C-glucosyl allothreonine was obtained by cleavage of the camphorsultam moiety.

We report the O-alkylation of oximes with Michael acceptors using Cs2CO3 as catalyst. The transformation proceeds stereospecifically retention oxime configuration. Irradiation visible light in presence diphenyl anthracene and cerium complexes affects E to Z configuration ratio ether products, but a complete stereocontrol was not achieved. operationally simple protocol allows synthesis various O...

Chlorotestosterone and its metabolites were determined in urine samples from bovine animals treated with chlorotestosterone acetate by oral and intramuscular routes. Sample preparation, involving enzymatic deconjugation and solid-phase extraction, was optimised. The effect of different enzyme preparations, pH, and time of incubation were studied. An extraction/clean-up procedure based on solid-...