Background: Atherosclerosis, a chronic inflammatory disease of the vessel wall is characterized by local and systemic immune responses to a variety of antigens. Oxidized low-density lipoprotein (oxLDL) is considered as an important determining factor in the pathogenesis of atherosclerosis. Objective: The purpose of this study was to investigate the degree of peripheral blood mononuclear cells (...

Inhibitory effect of ark shell (Scapharca subcrenata (Lischke, 1869)) proteolytic hydrolysates (ASHs) on oxidized low-density lipoprotein (oxLDL)-induced macrophage foam cell formation was investigated. Two types ASHs were prepared by Alcalase® and pepsin, ASAH (ark shell-Alcalase® hydrolysates), ASPH shell-pepsin hydrolysate). Oil Red O staining results showed that suppressed lipid accumulatio...

The prevalences of cardiovascular disease (CVD) and type 2 diabetes (T2D) have increased among the Navajo Native American community in recent decades. Oxidized low-density lipoprotein (oxLDL) is a novel CVD biomarker that has never been assessed in the Navajo population. We examined the relationship of oxLDL to conventional CVD and T2D risk factors and biomarkers in a cross-sectional population...

Background: Acute myeloid leukemia (AML) is blood and bone marrow malignancy. Low-density oxidative lipoprotein (oxLDL) is a pro-inflammatory factor that has free radicals in its structure. OxLDL levels are also rising in diseases such as diabetes, cardiovascular disease, and some cancers. Studies have shown that oxLDL and dyslipidemia are more common in patients with various cancers. This stud...

It has been shown previously that the binding of oxidized low-density lipoprotein (OxLDL) to resident mouse peritoneal macrophages can be inhibited (up to 70%) by the apoprotein B (apoB) isolated from OxLDL, suggesting that macrophage recognition of OxLDL is primarily dependent on its modified protein moiety. However, recent experiments have demonstrated that the lipids isolated from OxLDL and ...

background: elevated serum levels of oxidized low-density lipoprotein (oxldl) have been found in type 2 and in poorly controlled diabetic patients. gestational diabetes mellitus (gdm) has common features with type 2 diabetes. objective: the aim of our study was to evaluate the serum levels of oxldl in women with gdm compared to normal pregnant women. materials and methods: in this cross-section...

Oxidized LDL (oxLDL) performs critical roles in atherosclerosis by inducing macrophage foam cell formation and promoting inflammation. There have been reports showing that oxLDL modulates macrophage cytoskeletal functions for oxLDL uptake and trapping, however, the precise mechanism has not been clearly elucidated. Our study examined the effect of oxLDL on non-muscle myosin heavy chain IIA (MHC...

Zhang C, Adamos C, Oh MJ, Baruah J, Ayee MA, Mehta D, Wary KK, Levitan I. oxLDL induces endothelial cell proliferation via Rho/ROCK/Akt/p27 signaling: opposite effects of oxLDL and cholesterol loading. Am J Physiol Cell Physiol 313: C340 –C351, 2017. First published July 12, 2017; doi:10.1152/ ajpcell.00249.2016.—Oxidized modifications of LDL (oxLDL) play a key role in the development of endoth...

Background: This study investigated the association between long non-coding RNAs (lncRNAs) and coronary heart disease (CHD) further elucidated potential biological roles of lncRNAs in CHD pathogenesis. Methods: A case-control (590 patients 590 controls) was conducted from February 2017 March 2019 Fuzhou, China. Environmental factors were using questionnaires physical examinations. Five represen...

Oxidized low-density lipoprotein (oxLDL) is considered one of the principal effectors of atherogenesis. To explore mechanisms by which oxLDL affects human mononuclear phagocytes, we incubated these cells in medium containing oxLDL, acetylated LDL (acLDL), or native LDL, or on surfaces coated with these native and modified lipoproteins. The presence of soluble oxLDL, acLDL, or native LDL in the ...