Abstract Background Ustekinumab is a humanized antibody to p40 subunit shared by the cytokines IL-12 and IL-23, which has been approved for treatment of Crohn’s disease. While it presumed derive clinical efficacy blocking ability these stimulate specific T cell subsets, its actual effect upon human immune system not well-described. Methods Peripheral blood mononuclear cells (PBMC) were cryopres...

The muscle system is a complex network of highly specialised syncytial cells, the myofibers. These form by fusion of undifferentiated migratory myoblasts and subsequent organisation of contractile myofibrils. Many aspects of this complex, multi-step process remain poorly understood. With the development of genome-wide transgenic RNAi libraries in Drosophila, it is now possible to conduct a syst...

mechanisms of wing vein formation have been well studied in Drosophila melanogaster, however little is known about if the mechanisms are conserved to develop diversified wing vein patterns among insects. In Drosophila, Dpp, BMP2/4 ortholog, is initially expressed at longitudinal veins and later at crossveins to specify both veins during pupal stages. Using a GFP tagged Dpp, we first addressed h...