نتایج جستجو برای: p2 hmc tio2

تعداد نتایج: 39177  

2013
Sanchari Bhattacharyya Yiting Yu Masako Suzuki Nathaniel Campbell Jozef Mazdo Aparna Vasanthakumar Tushar D. Bhagat Sangeeta Nischal Maximilian Christopeit Samir Parekh Ulrich Steidl Lucy Godley Anirban Maitra John M. Greally Amit Verma

5-hydroxymethylcytosine (5-hmC) is a recently discovered epigenetic modification that is altered in cancers. Genome-wide assays for 5-hmC determination are needed as many of the techniques for 5-methylcytosine (5-mC) determination, including methyl-sensitive restriction digestion and bisulfite sequencing cannot distinguish between 5-mC and 5-hmC. Glycosylation of 5-hmC residues by beta-glucosyl...

2015
Asuka Murata Yoshifumi Baba Takatsugu Ishimoto Keisuke Miyake Keisuke Kosumi Kazuto Harada Junji Kurashige Shiro Iwagami Yasuo Sakamoto Yuji Miyamoto Naoya Yoshida Manabu Yamamoto Shinya Oda Masayuki Watanabe Mitsuyoshi Nakao Hideo Baba

Mammalian DNA is epigenetically marked by 5'-cytosine methylation (5-methylcytosine [5-mC]). The Ten-eleven translocation (TET) enzymes (TET1, TET2, and TET3) are implicated in DNA demethylation, through dioxygenase activity that converts 5-mC to 5-hydroxymethylcytosine (5-hmC). Although decreased TET is reportedly associated with decreased 5-hmC levels in various cancers, functions of 5-hmC an...

2015
Shaojie Chen Zhiyang Liu Ziyi Ge

Three 3,4-dithienyl-substituted polythiophene derivatives have been synthesized and characterized. Polymer P2 exhibits the widest light absorption spectrum of the polymers in its polymer chain, which has an alternative donor-acceptor structure. Copolymers blended with 6,6-phenyl-C71-butyric acid methyl ester(PC71BM) as active layers are used to fabricate polymer solar cells (PSCs), and a variet...

Journal: :BioTechniques 2010
Colm Nestor Alexey Ruzov Richard Meehan Donncha Dunican

DNA cytosine methylation (5mC) is highly abundant in mammalian cells and is associated with transcriptional repression. Recently, hydroxymethylcytosine (hmC) has been detected at high levels in certain human cell types; however, its roles are unknown. Due to the structural similarity between 5mC and hmC, it is unclear whether 5mC analyses can discriminate between these nucleotides. Here we show...

2017
Nilesh Tripuraneni Mark Rowland Zoubin Ghahramani Richard E. Turner

Hamiltonian Monte Carlo (HMC) exploits Hamiltonian dynamics to construct efficient proposals for Markov chain Monte Carlo (MCMC). In this paper, we present a generalization of HMC which exploits non-canonical Hamiltonian dynamics. We refer to this algorithm as magnetic HMC, since in 3 dimensions a subset of the dynamics map onto the mechanics of a charged particle coupled to a magnetic field. W...

2014
Milda Kaniusaite Eimantas Astromskas Gediminas Alzbutas Renata Bruzaite Arunas Lagunavicius

5-hydroxymethylcytosine (5-hmC) is an extensively studied DNA epigenetic modification. Here we present a novel tool which combined with next generation sequencing offers new ways of analyzing 5-hmC at the genomic level. We demonstrate that the Thermo ScientificTM EpiJETTM 5-hmC Enrichment Kit is highly specific for different DNA samples containing 5-hmC modifications. Our data shows that this t...

2014
Christof Seiler Simon Rubinstein-Salzedo Susan Holmes

The Jacobi metric introduced in mathematical physics can be used to analyze Hamiltonian Monte Carlo (HMC). In a geometrical setting, each step of HMC corresponds to a geodesic on a Riemannian manifold with a Jacobi metric. Our calculation of the sectional curvature of this HMC manifold allows us to see that it is positive in cases such as sampling from a high dimensional multivariate Gaussian. ...

2017
Yukihiro Ikeda

Received: July 11, 2016 Revised: February 20, 2017 Accepted: March 02, 2017 Abstract: Background: Domestic medical waste from Home Medical Care (HMC) is a concern in Japan. In 2005, the Japanese government provided that HMC waste is collected by municipalities. HMC waste includes infectious or sharps, thus such waste should be collected by doctor or nurse. Nevertheless, no studies have examined...

1996
Tetsuya Takaishi

The Hybrid Monte Carlo (HMC) algorithm[1] is now the standard method to simulate dynamical fermions. However the cost of the algorithm is substantial. It is therefore desirable to improve the efficiency of the HMC algorithm. First, we examine the possibility of changing the step size adaptively[2,3]. Second, we implement the HMC algorithm with approximate Hamiltonians. Lastly, we precondition t...

Journal: :Genes 2015
Dovilė Strepetkaitė Gediminas Alzbutas Eimantas Astromskas Arūnas Lagunavičius Rasa Sabaliauskaitė Kęstutis Arbačiauskas Juozas Lazutka

The aim of our study was to analyze the presence of 5-methyl-cytosine (5-mC) and 5-hydroxymethyl-cytosine (5-hmC) in the genome of crustacean Daphnia pulex. First, the presence of 5-mC and 5-hmC in genomic DNA was demonstrated by using antibodies specific to either 5-mC or 5-hmC. Then, analysis of 5-mC and 5-hmC using pairs of restriction enzymes with different sensitivity to methylation and hy...

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