Acetyltransferase p300 (KAT3B) plays key roles in signaling cascades that support cancer cell survival and sustained proliferation. Thus, p300 represents a potential anticancer therapeutic target. To discover novel anticancer agents that target p300, we conducted a high-throughput screening campaign. A library of 622,079 compounds was assayed for cytotoxicity to the triple-negative breast cance...

ABSTRACT Introduction: Several differences in the P300 component are observed when responses must be executed or inhibited in the Go/Nogo task. However, few studies were established by using well-controlled task with respect to the preparatory processing and stimulus probability. In the present study, we examined the peak amplitude and latency of Go-P300 (P300 evoked by visual Go stimuli) and N...

AIM In the present study, the P300 component of the emotion-loaded visual event-related potential in response to photographs of babies crying or smiling was measured to evaluate cognitive function in elderly subjects, including those with dementia. METHODS The subjects were 48 elderly people who consulted a memory disorder clinic. The visual event-related potential was measured using oddball ...

abstract introduction: several differences in the p300 component are observed when responses must be executed or inhibited in the go/nogo task. however, few studies were established by using well-controlled task with respect to the preparatory processing and stimulus probability. in the present study, we examined the peak amplitude and latency of go-p300 (p300 evoked by visual go stimuli) and n...

BACKGROUND Cognitive potential--P300 assessment in individuals with right hemisphere ischemic lesion due to ischemic stroke. AIM To characterize the cognitive potential--P300 in right-handed individuals with right hemisphere ischemic lesion, and to compare such data to those obtained in normal individuals. METHOD Anamnesis, conventional audiologic assessment and cognitive potential (P300) w...

Background: Scant and equivocal research exists examining the effects of button-pressing on P300. Button-pressing may decrease P300 latency and amplitude. The melding of motor potentials and P300 may also confound studies of P300 topography, such as studies of temporal scalp-area asymmetries in schizophrenia. Method: P300 was measured on button-press and silent-count tasks in control subjects. ...

The study was conducted to investigate the influence of type 2 diabetes mellitus on cognitive functions by measuring event related potential P300 (ERP P300) in 30 patients of type 2 diabetes mellitus aged 46-75 years with disease duration more than 5 years and compared them with control group. Diabetics had significantly longer P300 latency which was neither correlated with plasma glucose level...

The P300 (P3) wave of the auditory brain event-related potential was investigated in patients with probable Alzheimer's disease to determine whether P300 latency discriminated these patients from controls and whether prolonged P300 latency correlated with rates of brain glucose metabolism as measured by Positron Emission Tomography. P300 latency was prolonged by more than 1.5 standard deviation...

The auditory P300 evoked potential was recorded in 36 subjects: left(LH) and right-handed (RH) schizophrenic males and LH and RH normal controls. LH and RH normals showed no asymmetry in P300 scalp topography. LH and RH schizophrenics, however, showed lateralized asymmetries in temporal scalp regions: left < right P300 voltage asymmetry in RH schizophrenics and left > right P300 voltage asymmet...

Neuromarketing provides insights into consumers' decision-making that traditional marketing test methods cannot offer. The foundation in the process of is P300. Thus, P300 wave a potential Event-Related Component (ERP) used to measure process. represents positive transition human event-related potential. Therefore, determined by measuring amplitude and latency consumers. A higher indicates grea...