1. dept. of hematology, oncology, kermanshah university of medical sciences, kermanshah, iran 2. medical biology research center, kermanshah university of medical sciences, kermanshah, iran 3. students research committee, kermanshah university of medical sciences, kermanshah, iran     corresponding author: masoud sadeghi, msc; degree in biochemistry tel: (+91) 8338428221 email: sadeghi_mbrc@yah...

Paclitaxel is the one of the most common chemotherapeutic drugs used for the treatment of prostate cancer. However, its current clinical utility has been limited due to numerous serious side effects and drug resistance. Noscapine is an antitussive opium alkaloid that showed antitumor activity against a variety of cancer while has not exhibited severe side effects. This study investigates the a...

Paclitaxel is the one of the most common chemotherapeutic drugs used for the treatment of prostate cancer. However, its current clinical utility has been limited due to numerous serious side effects and drug resistance. Noscapine is an antitussive opium alkaloid that showed antitumor activity against a variety of cancer while has not exhibited severe side effects. This study investigates the a...

There is no other naturally occurring defense agent against cancer that has a stronger effectthan paclitaxel, commonly known under the brand name of Taxol®. The major drawback for themore widespread use of paclitaxel and its precious precursor, 10-deacetylbaccatin III (10-DABIII), is that they require large-scale extraction from different parts of yew trees (Taxus species),cell cultures, taxane...

aims: the backbone of treatment in advanced non-small cell lung cancer is platinum-based doublet chemotherapy. we intended to compare the effectiveness of two commonly used regimens in real world practice. methods: this single institute, parallel comparative post marketing study included 100 patients with chemo-naïve advanced (stage iiib, iv) non-small cell lung cancer and eastern cooperative o...

common yew taxus baccata l. is an evergreen, slow growing   tree, indigenous of hyrcanian forests in iran. discovery of paclitaxel as an   anti tumor agent in the bark of taxus has increased importance of this   plant for treatment of breast and ovary cancer, especially 7000 women die annually   due to breast cancer in iran. regarding destructive method of paclitaxel   production and protection...

Objective(s): Paclitaxel-induced peripheral neuropathy is a common adverse effect of cancer chemo -therapy. This neuropathy has a profound impact on quality of life and patient’s survival. Preventing and treating paclitaxel-induced peripheral neuropathy is a major concern. First- and second-generation antipsychotics have shown analgesic effects both in humans and animals. Quetiapine is a novel ...