Palmoplantar keratodermas (PPKs) are a large group of disorders characterized by hyperkeratosis of palms and soles. They can be classified by their mode of inheritance, the morphology and distribution of the hyperkeratosis (diffuse, focal or punctate), the involvement of other ectodermal structures, the presence or absence of associated nonectodermal features and the morphological findings at l...

Palmoplantar keratodermas (PPKs) represent a diverse group of hereditary and acquired disorders characterized by hyperkeratosis of the skin on the palms and soles [1]. The three major patterns of involvement are diffuse, focal and punctate. There are clinical distinguishing features for each disease in this group, for example, transmigration to areas beyond the palmoplantar skin. Also the exten...

Palmoplantar keratodermas are a heterogenous group of diseases, one of them is Papillon-Lefevre Syndrome (PLS). This rare disease is inherited as autosomal recessive and characterized by focal hyperkeratotic plaques on elbows and knees, severe periodontal disease resulting in premature loss of teeth. We report two brothers with PLS who did not have a history of this disease in their famil...

Palmoplantar keratoderma (PPK) is a heterogeneous group of hereditary and acquired disorders characterized by abnormal thickening of the palms and soles. There are three clinical patterns: diffuse, focal, and punctuate. Palmoplantar keratodermas can be divided into the following functional subgroups: disturbed gene functions in structural proteins (keratins), cornified envelope (loricrin, trans...

Sir, Palmoplantar keratodermas (PPKs) constitute a heterogeneous group of skin disorders with the distinctive trait of hyperkeratosis of palmoplantar skin. The disorders are classified clinically by the morphology and distribution of the hyperkeratosis, the presence of associated cutaneous and non-cutaneous features and by the mode of transmission (1, 2). Familial diffuse epidermolytic PPK (EPP...

Introduction: Palmoplantar keratodermas (PPK) constitute a clinically and genetically complex group of cornification disorders characterized by defective epidermal differentiation leading to marked palmoplantar hyperkeratosis. Classically, have been categorised as hereditary acquired forms. Case Presentation: A 12-year-old male patient presented our dermatology outpatient department with diffus...

Vohwinkel Syndrome (VS) is a type of diffuse hereditary palmoplantar keratodermas (DHPPK) accompanied by skeletal dimorphisms and sensorineural deafness. The most frequently reported genetic substrate in VS is a point mutation of GJB2 gene, responsible for encoding connexin 26, a gap-junction protein with a crucial role in neuronal migration in rats. We report the case of a 21-year-old male who...

A steadily growing number of hereditary palmoplantar keratodermas (PPKs) have been found to result from defective function epidermal adhesion proteins such as desmoglein 1 (DSG1), a critical component desmosomes which has implicated in the pathogenesis striate, diffuse and focal PPKs. Here we aimed at delineating genetic basis novel dominant form PPK. We studied three patients two families diag...