Metformin is becoming a popular treatment before and during pregnancy, but current literature on in utero exposure to metformin lacks long-term clinical trials mechanistic studies. Current the effects of mature pancreatic β-cells highlights its dual, opposing, protective, or inhibitory effects, depending metabolic environment. However, impact developing human remains unknown. In this study, we ...

Objective: Pancreatic b-cell dysfunction is described to be present at the diagnosis of type 2 diabetes mellitus (T2DM) and progressively deteriorated with disease duration. However, its progression is variable and potentially influenced by several factors. The Magnesium (Mg) deficiency mediates insulin resistance but reports regarding its role in pancreatic β-cell dysfunction are scarce and co...

Transcription factor Nrf2 (NF-E2-related factor 2) regulates wide-ranging cytoprotective genes in response to environmental stress. Keap1 (Kelch-like ECH-associated protein 1) is an adaptor protein for Cullin3-based ubiquitin E3 ligase and negatively regulates Nrf2. The Keap1-Nrf2 system plays important roles in the oxidative stress response and metabolism. However, the roles Nrf2 plays in prev...

Background and objectives: Prosopis farcta has been used as a traditional herbal medicine for treating diabetes mellitus.The aim of this study was investigating the antidiabetic mechanisms of infusion extract of P. farcta and discovering the active extract for the first time. Methods: Six different extracts of P. farcta were ...

background and aims: understanding β-cell function at the molecular level will likely facilitate the development of β-cells manufacture techniques. the aim of the present study was to investigate the pancreatic and duodenal homeobox 1 (pdx-1) gene expression into dtz-stained cellular clusters originating from emberyonal carcinoma cells. methods: this implemental -fundamental study was accomplis...

Proliferation of pancreatic β-cells is an important mechanism underlying β-cell mass adaptation to metabolic demands. Increasing β-cell mass by regeneration may ameliorate or correct both type 1 and type 2 diabetes, which both result from inadequate production of insulin by β-cells of the pancreatic islet. Transforming growth factor β (TGF-β) signaling is essential for fetal development and gro...

Pancreatic progenitor cell research has been in the spotlight, as these cells have the potential to replace pancreatic β-cells for the treatment of type 1 and 2 diabetic patients with the absence or reduction of pancreatic β-cells. During the past few decades, the successful treatment of diabetes through transplantation of the whole pancreas or isolated islets has nearly been achieved. However,...

the disposition and cellular organization of the endocrine pancreas were studied in three species of freshwater teleosts viz., labeo bata (hamilton, 1822), sperata aor (hamilton, 1822) and chitala chitala (hamilton, 1822) using histological techniques. in l. bata, the endocrine pancreas tissues were mainly distributed in the adipose tissue among the intestinal coils and adjacent to extrahepatic...