We used in vitro and in vivo approaches to examine whether tumor necrosis factor-a (TNF-a) and oncostatin M (OSM), cytokines that bind to distinct classes of receptors, differentially regulate expression of Pand E-selectin in murine and primate endothelial cells. In human umbilical vein endothelial cells, TNF-a rapidly increased mRNA for E-selectin but not P-selectin. OSM elicited little or no ...

UNLABELLED Coenzyme A (CoA) is essential for cellular chemistry in all forms of life. The pantothenate moiety of CoA is generated from the condensation of pantoate and β-alanine. β-Alanine is formed by decarboxylation of l-aspartate catalyzed by PanD, a pyruvoyl enzyme that is synthesized by the cell as an inactive precursor (pro-PanD). Maturation of pro-PanD into PanD occurs via a self-cleavag...

Through mutant selection on agar containing pyrazinoic acid (POA), the bioactive form of the prodrug pyrazinamide (PZA), we recently showed that missense mutations in the aspartate decarboxylase PanD and the unfoldase ClpC1, and loss-of-function mutation of polyketide synthases Mas and PpsA-E involved in phthiocerol dimycocerosate synthesis, cause resistance to POA and PZA in Mycobacterium tube...

If a nonsymmetric P-polynomial association scheme, or equivalently. a distanceregular digraph, has diameter d and girth g. then d = g or d = g 1, by Damerell’s theorem. The dual of this theorem was proved by Leonard. In this paper, we prove that the diameter of a nonsymmetric Pand Q-polynomial association scheme is one less than its girth and its cogirth. We also give a structure theorem for a ...

Median crust and upper mantle Pand S-wave delay times, based on residuals for teleseismic Pand S-wave arrival times included in the groomed ISC/NEIC database of Engdahl et al. [Bull. Seism. Soc. Am. 88 (1998) 722] are estimated as functions of time and azimuth for Eurasian seismic stations. The effects of source and lower mantle 3-D structure on the station residuals are corrected by ray tracin...

BACKGROUND Extended gastrectomy with para-aortic nodal dissection (PAND) or thorough dissection of mediastinal nodes using a left thoracoabdominal (LTA) approach is an alternative to D2 lymphadenectomy, with variable postoperative results. METHODS Two randomized controlled trials have been conducted to compare D2 lymphadenectomy alone (263 patients) versus D2 lymphadenectomy plus PAND (260), ...

Panic attacks are a hallmark in panic disorder (PAND). During the panic attack, a strong association with the surrounding context is established suggesting that the hippocampus may be critically involved in the pathophysiology of PAND, given its role in contextual processing. We previously showed that variation in the expression of the neurotrophin tyrosine kinase receptor type 3 (NTRK3) in bot...

Pilocarpine is commonly used after angle surgery for glaucoma Background: despite a host of side effects and risks. We hypothesized that a pharmacological miosis during the first two months does not improve shortand long-term results of trabectome-mediated trabeculectomy. ab interno In this retrospective comparative 1-year case series, we compared Methods: 187 trabectome surgery eyes with (P+) ...

OBJECTIVES This study evaluated the therapeutic significance of full lymphadenectomy in early-stage ovarian clear cell carcinoma (OCCC). METHODS We retrospectively reviewed records of 127 consecutive patients with pT1/pT2 and M0 OCCC who were treated between January 1995 and December 2015. We compared survival outcomes between those who did and did not undergo para-aortic lymph node dissectio...

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