Profilin has been described as an allergen present in pollen of trees, grasses and weeds. Since Parietaria judaica profilin has a molecular mass similar to other Parietaria allergens (Par j 1 and Par j 2) in the 14-10 kDa range, it is difficult to assess the prevalence of profilin by immunoblotting or to obtain sufficient amounts of purified native profilin for investigation and diagnosis. The ...

la polymerisation thermique des huiles siccatives, en particulier l'huile de lin, semble etre une reaction bien connue . tandis que la structure des macromolecules n'est pas encore definie avec precision. on a montre que, lors de la standolisation de l'huile de jin, il se forme des aeides dimeres (c36) et trirneres (c54) , par le mecanisme de la synthese dienique, l'etude ex...

BACKGROUND Poly-ADP-ribose (PAR) is a polymer synthesized by poly-ADP-ribose polymerases (PARPs) as a postranslational protein modification and catabolized mainly by poly-ADP-ribose glycohydrolase (PARG). In spite of the existence of cytoplasmic PARPs and PARG, research has been focused on nuclear PARPs and PAR, demonstrating roles in the maintenance of chromatin architecture and the participat...

The serine proteinase inhibitor tissue factor pathway inhibitor-2 (TFPI-2) inhibits the tissue factor-factor VIIa complex and thereby impairs factor Xa and subsequently thrombin generation. Here we show that thrombin itself up-regulates TFPI-2 mRNA and protein expression in human liver myofibroblasts, a cell type shown to express high levels of TFPI-2 (Neaud, V., Hisaka, T., Monvoisin, A., Bedi...

Recombinant allergens are a promising alternative to crude allergen extracts for diagnosis and therapy of allergic diseases. Genetically modified allergen derivatives with reduced allergenic activity but retaining their immunogenicity have also been produced to increase safety and specificity of allergen-specific immunotherapy. When a limited number of allergens are responsible for most of the ...

This contribution investigates no-rate-loss PAR reduction methods in terms of complexity and performance. In particular, a new method that achieves greater PAR reduction for less complexity than all other no-rate-loss PAR reduction schemes. Even with less complexity than the others (including Motorola's recent ITU/UAWG proposal in 1]), this new method has complexity feasible only for upstream A...

Dans le projet g~n~ral de Z. S. Harris (1968), nous avons ~ la base un ensemble K de phrases ~l~mentaires (les phrases noyaux) et un ensemble O, d~fini pour chaque langue naturelle, d'op~rateurs, de base. Une phrase est alors caract~ris~e par une unique d~composition (repr~sent~e par un treillis) obtenue par un produit des op6rateurs de base et des phrases ~l~mentaires de K. Ce qui caractSrise ...

Serine protease inhibitors (soybean trypsin inhibitor [STI] and Bowman-Birk protease inhibitor [BBI]) found in soybeans have been shown to inhibit melanosome phagocytosis by keratinocytes via protease-activated receptor 2 (PAR-2). Pre-clinical studies have confirmed the skin lightening potential of these molecules. In this study, we investigated the efficacy of a novel soy moisturizer containin...

MOST MEMBRANE RECEPTORS in mammalian systems are seventransmembrane domain G protein-coupled receptors. Proteinase (or protease)-activated receptors (PARs) are a novel family of G protein-coupled receptors. Unlike other G protein-coupled receptors that require ligand binding for activation, PARs are activated upon cleavage of their extracellular NH2 terminus by serine proteases such as thrombin...