BACKGROUND Four-dimensional computed tomography (4D-CT) provides both functional and highly detailed anatomic information about parathyroid tumors. The purpose of this study was to compare 4D-CT with sestamibi imaging and ultrasonography as methods for the accurate preoperative localization of hyperfunctioning parathyroid glands before parathyroidectomy. METHODS A study of 75 patients with pr...

J.C. Sillery D.R. DeLone K.M. Welker SUMMARY: We have encountered 2 cases of parathyroid adenomas that are atypical because of their large size, cystic character, and faint enhancement compared with the typical solid parathyroid adenomas. Specifically, the enhancement pattern of a typical parathyroid adenoma in a multiphasic scan demonstrates rapid arterial enhancement and rapid washout on dela...

Nuclear imaging of the thyroid and parathyroid glands has evolved from early radionuclide rectilinear thyroid scanning to the recently developed dual isotope subtraction technique for detecting parathyroid lesions. At the same time, x-ray fluorescent scanning, ultrasound, x-ray computed tomography, and magnetic resonance imaging have improved identification of these endocrine organs. The approp...

Scintigraphy of the parathyroid glands continues to be controversial from several standpoints, including radiopharmaceutical choice, imaging protocol, results, and utility in clinical situations. This article reviews: the anatomy, physiology and pathology of the parathyroid glands; mechanisms of radiopharmaceutical localization; commonly accepted imaging protocols; image results; and the approp...

Background: Hyperparathyroidism (HPT) is an endocrine disease characterized by a hypercalcemic state due to hyper secretion of parathyroid hormone. Imaging in parathyroid disease (hyperparathyroidism) is aimed at localizing enlarged parathyroid glands after a biochemical diagnosis of hyperparathyroidism has been made. By precisely identifying the number and location of abnormal parathyroid glan...

Key words: hyperparathyroidism-radionuclide-imaging; primary and secondary hyperparathyroidism [1–3]. With hyperplastic parathyroid glands tetrofosmin hyperplasia; Technetium-99m-diagnostic use; tetrofosmin imaging gives an overall sensitivity of 84% and a specificity of 75%, higher than those of Tc-99m sestam-ibi, ultrasonography and magnetic resonance imaging Renal history [1–2]. The former h...

BACKGROUND We investigated a novel technique, intraoperative (99 m)Tc-Sestamibi (MIBI) imaging (neck and excised specimen (ES)), using a large field-of-view portable gamma camera (LFOVGC), for expediting confirmation of MIBI-avid parathyroid adenoma removal. METHODS Twenty patients with MIBI-avid parathyroid adenomas were preoperatively administered MIBI and intraoperatively imaged prior to i...

UNLABELLED This study was undertaken to determine the effects of collimators on the accuracy of preoperative sestamibi parathyroid imaging of the neck. METHODS Forty-nine patients with primary hyperparathyroidism underwent preoperative (99m)Tc-sestamibi parathyroid imaging. The protocol included early and late pinhole and parallel-hole imaging. One experienced nuclear physician, without knowl...

UNLABELLED (99m)Tc-sestamibi dual-phase scintigraphy is currently established for parathyroid localization. However, the imaging technique is not standardized, and the role of the pinhole collimator, especially, is not fully recognized in the imaging protocol. The aim of this study was to check whether the use of a pinhole collimator in parathyroid scintigraphy would enhance lesion detectabilit...