objective: to investigate the correlation between lower and higher order sensory functions and manual dexterity as well as to identify the sensory measures that could predict manual dexterity in patients with idiopathic parkinson’s disease (pd). materials and methods: in this cross-sectional study, 55 patients with idiopathic pd by mean age of 59.85 ± 11.89 years, and mean hoehn and yahr stage ...

Studies of modest size and scope are challenging. When addressing questions unlikely to be soon answered by level 1 evidence from a multicenter randomized trial, the data they generate may be influential despite reservations about their limitations. By asking our commentators to address the clinical relevance of such studies, which are particularly well represented in this issue of PD Monitor &...

Parkinson’s Disease (PD) is a chronic, progressive, neurodegenerative disorder with motor and non-motor signs and symptoms. PD is caused by idiopathic degeneration of dopamine-producing cells in the substantia nigra, located in the midbrain. Recently, Trace elements have been recognized to play an important role in the development of Parkinson’s disease (PD). The aim of this review ...

parkinson`s disease (pd) is the second most common neurodegenerative disorder after alzheimer`s disease. it is a chronic and progressive disease, and mostly afflicts elderlies. pd starts with sudden onsets and the exact cause of the disease is still unknown, however there are some early symptoms that can help us to diagnose the disease and ameliorate its effects. pd is a multi-factorial disease...

Background. Previous surveys have shown that motor deficits precede the classical motor symptoms seen in Parkinson’s disease (PD) and that physical exercise may have beneficial effects on PD. Objectives. Here, we evaluated the potential of voluntary exercise to improve motor deficit in experimentally-induced Parkinson’s disease (6-OHDA) rats. Methods. Forty adult Wistar rats were ...

background: vitamin d is an important factor responsible for many physiologic functions. vitamin d deficiency is associated with increased risk of neurodegenerative disease. the level of vitamin d in iranian patients with parkinson's disease and its relationship with severity of symptoms and signs were evaluated in this study. methods: eighty-three patients with parkinson's disease (pd) were re...

introduction: one of the most common syndromes in parkinson's disease (pd) is rigidity. currently, an index is used to evaluate the level of pd by the clinical measurement of rigidity in the upper extremity. the index uses a subjective method called unified parkinson's disease rating system (updrs). the subjective nature of this method makes the influence of physician in the measureme...

background: parkinson's disease is one of the prevalent degenerative diseases of the neural system. oxidative stress, which has been recognized as the most important factor of parkinson's disease, plays a main role in the death of neurons in this disease. antioxidants have a proved role in the prevention of oxidative stress. objective: considering the presence of evidence regarding antioxidant ...