OBJECTIVE To compare the effectiveness of pain exposure physical therapy (PEPT) with conventional treatment in patients with complex regional pain syndrome type 1 (CRPS-1) in a randomised controlled trial with a blinded assessor. SETTING The study was conducted at a level 1 trauma centre in the Netherlands. PARTICIPANTS 56 adult patients with CRPS-1 participated. Three patients were lost to...

The abundance of the oligopeptide transporter (Pept-1) in the brush-border membrane of the intestinal epithelium is the central mechanism for regulation of transport of products of protein digestion (dipeptides and tripeptides) and peptidomimetic drugs (for example, beta-lactam antibiotics). Within the past few years, there has been substantial progress in identifying the factors controlling th...

We present a high-level RPC architecture. Although RPC systems seem quite varied they actually share the same fundamental building blocks. We examine the operation of several technologies (e.g., SOAP/HTTP, RMIIIOP) to show what they have in common, namely four main blocks that we call PEPt: Presentation, Encoding, Protocol and transport. Presentation encompasses the data types and APIs availabl...

Protein hydrolysis and amino acid metabolism contribute to the beneficial effects of sourdough fermentation on bread quality. In this work, genes of Lactobacillus sanfranciscensis strain DSM 20451 involved in peptide uptake and hydrolysis were identified and their expression during growth in sourdough was determined. Screening of the L. sanfranciscensis genome with degenerate primers targeting ...

13 Milling is a critical process for controlling the properties of the granules produced by roll 14 compaction. In the current study, the positron emission particle tracking (PEPT) technique was 15 used to examine the milling kinematics of roll compacted ribbons at various milling speeds. 16 Microcrystalline cellulose (MCC, Avicel PH-102) was used as the model feed material and a 17 radioactive...

We have analyzed the genetic basis for T cell recognition of an endogenous major histocompatibility complex class II-restricted self peptide. Transgenic mice expressing the influenza virus PR8 hemagglutinin I-Ed-restricted determinant $1 (HA Tg mice) mediate negative selection ofPR8 Sl-specific T cells, but respond to immunization with a virus containing a closely related analogue, $1(Kl13). Se...

A method for Positron Emission Particle Tracking (PEPT) based on optical feature point identification techniques is demonstrated for use in low activity tracking experiments. A population of yeast cells of approximately 125,000 members is activated to roughly 55 Bq/cell by 18F uptake. An in vitro particle tracking experiment is performed with nearly 20 of these cells after decay to 32 Bq/cell. ...

The utilization of exogenous peptides was studied in mutants of Lactococcus lactis in which combinations of the peptidase genes pepN, pepC, pepO, pepX and pepT were deleted. Multiple mutants lacking PepN, PepC, PepT plus PepX could not grow on peptides such as Leu-Gly-Gly, Gly-Phe-Leu, Leu-Gly-Pro, Ala-Pro-Leu and Gly-Leu-Gly-Leu, respectively, indicating that no other peptidases are present to...

The optical density of a culture of lactococcus lactis MG1363 was reduced more than 60% during prolonged stationary phase. Reduction in optical density (autolysis) was almost absent in a culture of an isogenic mutant containing a deletion in the major autolysin gene, acmA. An acmA mutant carrying multiple coples of a plasmid encoding AcmA lysed to a greater extent than the wild-type strain did....