Perforating dermatoses (PD) represent a rare group of papulonodular skin diseases with a distinct central keratotic core. The core represents the transepidermal elimination of an altered dermal substance.1 Diagnosis is established via biopsy and histopathologic evaluation. Whereas primary PD are diseases chiefly characterized by transepidermal elimination, secondary PD are a group of unrelated ...

Acquired perforating dermatosis (APD) is a disorder of transepidermal elimination keratin, collagen or elastic fibers. APD mainly associated with diabetes mellitus and chronic kidney disease. We present the case 66-year-old male, poorly controlled diabetic peripheral arterial disease, obesity, hypertension, Cushing's syndrome disease requiring hemodialysis who develops an acquired dermatosis. D...

Sir, Cutaneous manifestations are frequently found in patients with chronic renal failure. They can be classified as specific disorders (e.g. perforating disorders, metastatic calcification, bullous dermatosis) or non-specific disorders (e.g. skin colour changes, pruritus, elastosis, equimosis, xerosis, uraemic frost, half and half nails). We report here an unusual association between an acanth...

Acquired Perforating Dermatosis (APD) is a perforating disease characterized by transepidermal elimination of dermal material [1,2]. This disease usually develops in adulthood. APD has been reported to occur in association with various diseases, but is most commonly associated with dialysis-dependent chronic renal failure (CRF) or diabetes mellitus (DM) [1,2,3,4]. Morton et al found that APD oc...

Acquired perforating dermatosis characterised by the transdermal excursion of dermal material which clinically presents as umbilicated skin-coloured papules with a central white crust. A 45 year old male patient with diabetic nephropathy presented with similar lesion and itching. Diagnosis was confirmed by biopsy from appropriate site. Patient responded well to emollients, low dose-retinoids, b...