The surgical indications in 770 patients with Crohn's disease undergoing intestinal resection at The Mount Sinai Hospital from 1960-83 have been reviewed. Surgical indications were divided into two principal categories: 375 cases with perforating indications and 395 cases non-perforating. Among 292 patients who underwent second operations for recurrent Crohn's disease, the indications for secon...

Perforating necrobiosis lipoidica (PNL) is a very rare variant of necrobiosis lipoidica (NL), almost always associated with diabetes. A non-diabetic 43-year-old man referred to us with a gradually enlarging plaque on his forehead. The patient was initially diagnosed with cutaneous tuberculosis based on the histopatholo

ARPC: acquired reactive perforating collagenosis RPC: reactive perforating collagenosis INTRODUCTION Acquired reactive perforating collagenosis (ARPC) is a type of perforating disorder that is often associated with underlying systemic diseases, such as diabetes mellitus, renal failure, or malignancy. Giant variants of ARPC may reach up to 2 cm in size and have been reported in only a handful of...

Examination of the skin and nails can reveal many abnormalities in patients with end-stage renal disease that precede or follow initiation of dialysis treatment or kidney transplantation. This article focuses on specific and nonspecific cutaneous signs of end-stage renal disease, reviewing both banal and life-threatening conditions, including pruritus, perforating disorders, calcifying disorder...

Background Strongyloides stercoralis, a geohelminth which affects humans, has a cosmopolitan distribution in the tropical and subtropical areas but is sporadic in temperate countries like Romania. Acquired perforating disorders are a group of uncommon skin conditions characterized by transepidermal extrusion of dermal components, usually occurring in patients with chronic renal failure and/or d...

Acquired reactive perforating collagenosis is a perforating dermatosis usually associated with different systemic diseases, mainly diabetes mellitus and/or chronic renal insufficiency. Different therapies have been tried but treatment is not standardized yet and remains a challenge. In the last few years, allopurinol has been reported as a good therapeutic option for acquired reactive perforati...

Diabetes mellitus increases the risk of cerebrovascular disease, the effects of hypercapnia on CBF (cerebral blood flow) and cerebrovascular reactivity during diabetes are still inconsistent. Here, we have established a new microangiographic technique using synchrotron radiation (SPring-8, Japan), which enabled us to visualize rat cerebral vessels with high spatial resolution in real time. The ...

A perforating vein can become incompetent due to hemodynamic or morphologic causes. Until recently all perforating veins with a diameter exceeding 3 mm at ultrasound exam were considered incontinent(1). Since introduction of duplex doppler and color doppler investigations this hypothesis was temperated because the dilatation of one or more perforating veins was usually observed in chronic venou...

OBJECTIVE In microvascular decompression for hemifacial spasm, the perforating branches around the facial nerve root exit zone occasionally complicate facial nerve decompression. In this context, the vertebrobasilar configuration was retrospectively correlated with the perforating branches. METHODS Based on vertebral angiography, magnetic resonance angiography, and three dimensional computed ...