Periampullary Cancer is the term used for neoplasms arising from the head of pancreas, ampulla of Vater, distal bile duct and periampullary region of duodenum. Of these, the pancreatic adenocarcinoma carries the worst prognosis with majority of mortalities within the first year. The overall 5 year survival is less than 3%. Studies have shown that pancreatic carcinoma has the shortest median sur...

Differentiating between periampullary carcinoma and chronic pancreatitis with an inflammatory mass is difficult. Consequently, 6% to 9% of pancreatic resections for suspected carcinoma are done inappropriately for chronic pancreatitis. Here, we test if matrix metalloproteinase 7 (MMP-7), a secreted protease frequently expressed in pancreatic carcinoma, can be measured in plasma, pancreatic, and...

Reactive perforating collagenosis is one of the perforatingdermatoses; the acquired form is characterized by transepithelialelimination of altered collagen bundles. It has been seen inassociation with multiple disorders including diabetes mellitus,renal failure, hyperparathyroidism, liver disease, neurodermatitis,IgA nephropathy, and periampullary carcinoma with jaundice.According to the litera...

Ascarias lumbricoides infestation is endemic in tropical countries. Most infections are asymptomatic, but it can produce a wide spectrum of manifestations including hepatobiliary and pancreatic complications. There are reports of association of biliary ascariasis with bilary malignancies in the past, but same is not known for pancreatic ascariasis. We report a case of association of periampulla...

BACKGROUND Free tumour cells in the peritoneal cavity of patients with pancreatic carcinoma carry a poor prognosis. Reactive or degenerative mesothelial cells can make cytological interpretation with conventional stains difficult. Detection of the tumour-associated antigens carcinoembryonic antigen (CEA) and CA19-9 may improve detection. METHODS At staging laparoscopy, 22 patients with pancre...

OBJECTIVE The majority of the tumors in periampullary region are pancreatic and ampulla of Vater carcinomas. The aim of this study was to compare histopathological features of ampulla of Vater carcinomas with pancreatic ductal adenocarcinomas and to determine diagnostic and predictive values of p16 protein and cyclin D1 expression. MATERIAL AND METHOD Tissue samples from pancreatic ductal ade...

Agenesis of dorsal pancreas is a rare developmental anomaly. We here report a case of agenesis of dorsal pancreas in a patient of periampullary carcinoma and highlight its implications on the management.

Ductal adenocarcinoma is the most common primary malignant disease of the pancreas and periampullary region. It accounts for more than 75% of all nonendocrine tumors arising in this region, which includes the pancreas, the ampulla of Vater, the distal common bile duct, and the perivaterian duodenum. Pancreatic adenocarcinoma is the most common of the periampullary neoplasms. In the United State...