A case of periodic hypersomnia in an 11-year-old female with the unique features of mental deficiency, incontinentia pigmenti, acanthosis nigricans and hereditary multiple exostosis (diaphysial aclasis) is reported. The clinical, polysomnographic and Multiple Sleep Latency test features of this case with a follow up of seven years are consistent with a diagnosis of periodic (intermittent) exces...

M. Engström, T. Karlsson, and A-M. Landtblom IMH/Radiological Sciences/CMIV, Linköping University, Linköping, Sweden, Behavioural Sciences and Learning/CMIV, Linköping University, IKE/Neurology/CMIV, Linköping University Introduction The Kleine–Levin Syndrome (KLS) is a rare but relatively well-defined disorder characterised by excessive sleep periods (periodic hypersomnia) associated with beha...

ABBREVIATIONS : AASM 5 American Academy of Sleep Medicine ; CRSWD 5 circadian rhythm sleepwake disorder ; CSA 5 central sleep apnea ; CSB 5 Cheyne-Stokes breathing ; ICD 5 International Classification of Diseases ; ICSD 5 International Classification of Sleep Disorders ; IH 5 idiopathic hypersomnia ; MSLT 5 multiple sleep latency test ; NREM 5 non-rapid eye movement ; OCST 5 out-ofcenter sleep ...

The review deals with idiopathic hypersomnia, focusing mostly on the research findings about presence, onset and severity of excessive daytime sleepiness depressive symptoms in patients hypersomnia.

Background: Periodic hypersomnias in children and adolescents are described according to etiological groups like: 1) idiopathic the Kleine Levin syndrome (KLS) and its clinical variants 2) organic and 3) other psychiatric conditons. KLS is described as a triad of recurrent hypersomnolence, hyperphagia, and hypersexuality. However, an incomplete presentation characterized by hypersomnia without ...

BACKGROUND Hypersomnia in inter-episode bipolar disorder has been minimally researched. The current study sought to document the prevalence of hypersomnia in a sample of inter-episode patients with bipolar disorder and to examine the relationship between hypersomnia and future bipolar depressive symptoms. METHODS A total of 56 individuals with bipolar disorder (51 type I+5 type II) who were c...

CONTEXT Narcolepsy, a neurological disorder affecting 1 in 2000 individuals, is associated with HLA-DQB1*0602 and low cerebrospinal fluid (CSF) hypocretin (orexin) levels. OBJECTIVES To delineate the spectrum of the hypocretin deficiency syndrome and to establish CSF hypocretin-1 measurements as a diagnostic tool for narcolepsy. DESIGN Diagnosis, HLA-DQ, clinical data, the multiple sleep la...

INTRODUCTION Both narcolepsy and idiopathic hypersomnia are the main causes of excessive daytime sleepiness. In this study, we aimed to compare polysomnography (PSG) and multiple sleep latency test (MSLT) findings in narcolepsy and idiopathic hypersomnia patients. METHODS The files of patients with narcolepsy and hypersomnia who were admitted between 1995 and 2009 were reviewed. We evaluated ...