The major goal of periodontal therapy is periodontal regeneration including regeneration of alveolar bone, cementum and periodontal ligament fibres. Recapitulation of embryology shows the importance of Hertwig's epithelial root sheath (HERS), involved in cementogenesis and root formation. The remnants of these cells are found in normal periodontal ligament as the epithelial cell rests of Malass...

stem cell-based therapy has great potential in treating health conditions including cardiovascular, autoimmune, type i diabetes, neurodegenerative and bone and cartilage diseases also in spinal cord injuries, malformations and cancer. in addition to their potential use to treat systemic diseases, stem cell-based therapy also provides a powerful tool to treat oral and dental diseases such as cra...

Stem cell-based therapy has great potential in treating health conditions including cardiovascular, autoimmune, type I diabetes, neurodegenerative and bone and cartilage diseases also in spinal cord injuries, malformations and cancer. In addition to their potential use to treat systemic diseases, stem cell-based therapy also provides a powerful tool to treat oral and dental diseases such as cra...

Background: Stem cells have been widely used in various fields of the health sector, one which is dental health. Teeth with malocclusion require orthodontic treatment to achieve good function and aesthetics. Orthodontic tooth movement (OTM) occurs due a bone remodeling process, namely deposition areas tension resorption pressure. Differentiated stem are thought influence OTM through several dif...

A new nanostructured hydroxyapatite-coated porcine acellular dermal matrix (HAp-PADM) was fabricated by a biomimetic mineralization method. Human periodontal ligament stem cells were seeded on HAp-PADM and the effects of this scaffold on cell shape, cytoskeleton organization, cell viability, and osteogenic differentiation were examined. Periodontal ligament stem cells cultured on HAp-PADM exhib...

Objective- Investigating of the isolation, culture, differentiation potential and electronic microscopic characterization of canine periodontal ligament stem cells (PDLSCs). Design- Experimental in vitro study Animals- Four intact, male, mongrel dogs, 8-10 months-old were selected to collect PDLSCs from their teeth. Procedures- The dogs were anesthetized and the first maxillary and mandibula...

Dentistry is likely to be revolutionized by biological therapies based on growth and differentiation factors that accelerate and/or induce a natural biological regeneration. Induced pluripotent stem cell-based therapy for treating genetic disorders has become an interesting field of research in recent years. However, there is a paucity of information regarding the applicability of induced pluri...

Millions of people experience consequential tooth loss related to irretrievable damage of the periodontium caused by deep caries, severe periodontal diseases or irreversible trauma, resulting in a decreased quality of life. Hence, dental scientists have focused much attention on tissue engineering techniques in an effort to address this condition. The periodontium is composed mainly of two soft...