Amelogenin, the major component of a commercial enamel matrix derivative (Straumann® Emdogain), is commonly employed in periodontology. It is mainly used in periodontal surgery to stimulate the regeneration of periodontal tissues, including the cementum, periodontal ligament, and alveolar bone. However, the precise molecular mechanisms underlying amelogenin-induced regeneration have not yet bee...

Periodontal regeneration is a technique that aims to regenerate the damaged tissue around periodontally compromised teeth. The regenerative process use scaffolds, cells, and growth factors enhance biological activity.

Periodontitis is a chronic inflammatory disease that induces the destruction of tooth-supporting tissues, followed by tooth loss. Although several approaches have been applied to periodontal regeneration, complete periodontal regeneration has not been accomplished. Tissue engineering using a combination of cells and scaffolds is considered to be a viable alternative strategy. We have shown that...

Human periodontal ligament stem cells (hPDLSCs) transplantation represents a promising approach for periodontal regeneration; however, the cell source is limited due to the invasive procedure required for cell isolation. As human umbilical cord mesenchymal stem cells (hUCMSCs) can be harvested inexpensively and inexhaustibly, here we evaluated the regenerative potentials of hUCMSCs as compared ...

AIM The aim was to review the significance of the platelet derived growth factor (PGDF) in periodontal tissue regeneration. METHODS AND RESULTS Databases were searched using the following terms in different combinations: "growth factors", "guided bone regeneration", "guided tissue regeneration", "periodontal", "platelet rich plasma" and "platelet derived growth factor". Titles and abstracts o...

Chronic periodontitis is an inflammatory disease, resulting in destruction of the supporting structures of teeth. The ultimate goal of periodontal therapy is the regeneration of these lost structures. Stem cells are the latest entrant in periodontal regeneration. Amongst which, Dental Mesenchymal Stem Cells (DMSC) are currently the focus of research as these cells can be harvested with consider...

Introduction Periodontal regeneration is the reproduction or reconstitution of a lost or injured part of the periodontium so that the form and function of lost structures is restored. Many procedures have been attempted to achieve periodontal regeneration, including root surface conditioning, bone graft placement, guided tissue regeneration (GTR) and growth factor application. Current regenerat...

Periodontal regeneration is an important part of regenerative medicine, with great clinical significance; however, the effects of nanotopography on the functions of periodontal ligament (PDL) stem cells (PDLSCs) and on PDLSC sheet based periodontal regeneration have never been explored. Titania nanotubes (NTs) layered on titanium (Ti) provide a good platform to study this. In the current study,...

The regeneration or restitution of lost supporting tissue has always been considered the ideal objective of periodontal therapy. However, attempts to convert this intention into solid clinical practice can become tremendously complex, the results of which are very different from the original intention. The aim of this article is to offer an up-to-date, general perspective on periodontal regener...