background: considering the common origin of skin and peripheral nervous system, a tube of dermal layer of skin hypothetically can be an ideal conduit for nerve reconstruction. an experimental study performed to evaluate the nerve regeneration of efficacy into a dermal tube. methods: sixty male wistar rats were used. a 10 mm gap was produced in right sciatic nerves. in group a the autogenous ne...

Peripheral nerve damage (PNI) can cause demyelination, axonal degeneration and loss of motor sensory function. Melatonin with its antioxidative effect, has been reported to reduce scar formation in injury, take a role repair process by suppressing fibroblast proliferation the damaged area. It was aimed investigate effect melatonin peripheral relationship between S100 proteins angiogenic regulat...

The hypothesis is that induced pluripotent stem cells (iPSC) derived Schwann cells and/or macrophages can be transplanted into acellular nerve graft in repairing injured nervous system. The efficiency of iPSC seeded acellular nerve graft may mimic the autologous peripheral nerve graft.

Injuries to peripheral nerves are common and cause life-changing problems for patients alongside high social and health care costs for society. Current clinical treatment of peripheral nerve injuries predominantly relies on sacrificing a section of nerve from elsewhere in the body to provide a graft at the injury site. Much work has been done to develop a bioengineered nerve graft, precluding s...

conclusions our results support the use of pns in some patients with refractory chronic headaches. appropriate surgical planning and technique are important to achieve good clinical outcome and to minimize complications. background subcutaneous peripheral nerve stimulation (pns) has emerged as a useful tool in the treatment of intractable headaches. however, complications such as skin erosion, ...

INTRODUCTION Peripheral nerve injuries are encountered frequently in clinical practice. In nerve repair, an end-to-end suture is the preferable choice of treatment. However, where primary closure is not possible, the defect is to be repaired with a nerve graft. METHODS A total of 21 female Wistar rats weighing 230 to 290 g were used in the study. They were classified into the following 3 grou...

traumatic peripheral nerve injuries are among most important cause of physical disability among young adults. most partial injuries and some complete injuries recover without operative intervention, with early return of function appearing to be the most significant prognostic factor in these cases. return of function over time depends to a great extent on the underlying neuropathologic conditio...

BACKGROUND Peripheral nerve repair outcomes are suboptimal in the presence of severe soft tissue injury and excessive scarring paralleling the process in tendon reconstruction of the hand. Inspired by the advantages of the two-stage technique in tendon grafting and with encouraging preliminary results, we aimed to investigate the two-stage nerve grafting technique as an alternative method of se...