more toxic by intraperitoneal injection than any of the simple peroxides with which it was compared. Autoxidized methyl linoleate was less toxic than most of the simple peroxides. 5. The LD50 of autoxidized linoleic acid (0.26 ,mole of peroxide/g.) was only slightly higher than the mean increase of peroxide previously found in mice after 950r. of X-rays (0.22 lamole/g.). 6. Injected peroxides k...

Free radical-initiated lipid autoxidation in low density lipoprotein (LDL) has been implicated in the pathogenesis of atherosclerosis. Oxidation of the lipid components of LDL leads to a complex mixture of hydroperoxides, bicyclic endoperoxides, monocyclic peroxides, and serial cyclic peroxides. The oxidation compounds and/or their decomposition products can modify protein components, which may...

It has been considered that a great deal of factors are concerned with pathogenesis. Aging is intimately involved with atherogenesis. There are many theories of aging mechanism, one of which is free radical theory. Auto-oxidation of fatty acid proceeds by a free-radical mechanism with formation of peroxides. X-ray irradiation, that is known to shorten lifespan, accelerates the peroxidation. Toc...

This review is the first to collate and summarize main data on named and unnamed rearrangement reactions of peroxides. It should be noted, that in the chemistry of peroxides two types of processes are considered under the term rearrangements. These are conventional rearrangements occurring with the retention of the molecular weight and transformations of one of the peroxide moieties after O-O-b...

Solvent systems are described which permit class separations of various peroxidized lipids by thin-layer chromatography. This procedure has proved useful in biological studies and for testing the deterioration of lipids. Proof is given that the least polar peroxides of methyl esters, glycerides, and fatty acids are monoperoxides; it is then assumed that the least polar peroxides in the other te...

We hypothesize tha t prostacyclin (PG I2) is an anti-atherosclerotic hormone and that atherosclerosis develops when endothelial P G I2 synthetase is inhibited by lipid peroxides. Serum lipid peroxides occur in low-density lipoproteins (LDL). LDL lipid peroxides are elevated in common types of hyperlipoproteinaemias, P G I2 generation is im paired in atherosclerosis, and infusion of synthetic P ...

alkyl imidazolines have been reportedly used in a wide range of industrial formulations with different applications. ethoxylated alkyl imidazolines with appropriate ethoxylation degrees can be used as antioxidants and retarders in the formation of peroxides resulting from oxidation in hydrocarbon media. in this work, ethoxylated imidazolines were shown to be more effective in hydrocarbon media ...

The effect of curcumin administration in reducing the serum levels of cholesterol and lipid peroxides was studied in ten healthy human volunteers, receiving 500 mg of curcumin per day for 7 days. A significant decrease in the level of serum lipid peroxides (33%), increase in HDL Cholesterol (29%), and a decrease in total serum cholesterol (11.63%) were noted. As curcumin reduced serum lipid per...

We hypothesize tha t prostacyclin (PG I2) is an anti-atherosclerotic hormone and that atherosclerosis develops when endothelial P G I2 synthetase is inhibited by lipid peroxides. Serum lipid peroxides occur in low-density lipoproteins (LDL). LDL lipid peroxides are elevated in common types of hyperlipoproteinaemias, P G I2 generation is im paired in atherosclerosis, and infusion of synthetic P ...

BACKGROUND Peroxides have been reported to contaminate lipid emulsions and amino acid solutions used in total parenteral nutrition (TPN). This is particularly disturbing in newborn infants who are prone to several diseases related to immature defense mechanisms against oxidative challenges. It is not clear whether the antioxidants in multivitamins help protect parenteral nutrients against the h...