objective(s):this study was designed to investigate the effect of phaleria macrocarpa aqueous extract (pm) on spermatogenesis by observing the histological changes of testes in adult male rats. materials and methods: pm was prepared by boiling the dried slices of p. macrocarpa fruits followed by filtering, centrifugation and freeze-drying to obtain the powder form. eighteen sprague dawley adult...

In recent years, the utilization of certain medicinal plants as therapeutic agents has drastically increased. Phaleria macrocarpa (Scheff.) Boerl is frequently used in traditional medicine. The present investigation was undertaken with the purpose of developing pharmacopoeial standards for this species. Nutritional values such as ash, fiber, protein, fat, and carbohydrate contents were investig...

PURPOSE The purpose of this study was to determine the effects of Phaleria macrocarpa (PM) on male fertility by assessing its effect on the sperm characteristics which included the sperm count, motility, viability and morphology. METHODS Eighteen male rats were equally divided into three groups. Each group of rats was orally supplemented for 7 weeks either with PM aqueous extract (240 mg/kg),...

An earlier anti-hyperglycemic study with serial crude extracts of Phaleria macrocarpa (PM) fruit indicated methanol extract (ME) as the most effective. In the present investigation, the methanol extract was further fractionated to obtain chloroform (CF), ethyl acetate (EAF), n-butanol (NBF) and aqueous (AF) fractions, which were tested for antidiabetic activity. The NBF reduced blood glucose (p...

Mahkota dewa (Phaleria macrocarpa) merupakan tanaman perdu yang berasal dari family Thymelaceae. Senyawa bioaktif terkandung di dalam ini dapat digunakan sebagai obat. Penelitian bertujuan untuk mengetahui kandungan golongan senyawa dan aktivitas antioksidan ekstrak metanol daging buah mahkota dewa. Metode penelitian yaitu ekstraksi dengan pelarut metode 1,1-difenil-2-pikrilhidrazyl (DPPH) uji ...

BACKGROUND The edible fruits of Phaleria macrocarpa (Scheff.) Boerl are widely used in traditional medicine in Indonesia. It is used to treat a variety of medical conditions such as - cancer, diabetes mellitus, allergies, liver and heart diseases, kidney failure, blood diseases, high blood pressure, stroke, various skin diseases, itching, aches, and flu. Therefore, it is of great interest to de...

A common plant from Papua, Indonesia, called Phaleria macrocarpa (mahkota dewa), has potent therapeutic components. The aim of this study was to evaluate the toxicity level nanoherbal mahkota dewa and its effect on changes in hematology, biochemistry, electrolytes, histopathology organ. High Energy Milling (HEM) used produce dewa. LD50 determined three stages: dose orientation test (12 mice), p...

The wound-healing potential of Phaleria macrocarpa was evaluated by monitoring the levels of inflammatory mediators, collagen, and antioxidant enzymes. Experimentally, two-centimeter-wide full-thickness-deep skin excision wounds were created on the posterior neck area of the rats. The wounds were topically treated with gum acacia as a vehicle in the control group, intrasite gel in the reference...

BACKGROUND DLBS1442, a proprietary and standardized semipolar bioactive extract of the fruit Phaleria macrocarpa, is preclinically proven to have anti-inflammatory properties. The current clinical study evaluated the efficacy and safety of DLBS1442 in alleviating symptoms of premenstrual syndrome and primary dysmenorrhea. METHODS This was an open study over four menstrual cycles (with two con...