the aim of this work was to develop and evaluate a minoxidil foamable emu oil emulsion with the purpose of improving minoxidil permeation into the skin, increasing hair growth , reducing skin irritation, and increasing consumer compliance. minoxidil was dissolved in a solvent system comprising ethanol: glycerin: lactic acid: water (10:20:5:65). the foamable emulsion was prepared by mixing the o...

Since the discovery of the anticancer activity of titanocene dichloride (TDC), many derivatives have been developed and evaluated. MKT4, a soluble, water-stable formulation of TDC, was used for both Phase I and Phase II human clinical trials. This formulation is investigated here by using (1)H and (13)C NMR, FT-ICR mass spectrometry, and UV/vis-detected pH-dependent speciation. DFT calculations...

The drivers to produce solid solution formulations are reviewed together with specific challenges of implementing extrusion in a pharmaceutical setting. A solvent-based approach to screen formulations with less than 10 mg drug/screen is introduced and validated with experimental data. Process development challenges associated with the use of hygroscopic fine polymer powders are addressed throug...

Background and objectives: Hemorrhoids is the most painful rectal disease. Straining and pregnancy seem playing chief roles in the development of hemorrhoids. Symptoms of hemorrhoids may include bleeding, inflammation and pain. Despite current medical efforts, many discomforts of hemorrhoids have not been handled. The aim of the present study was to formulate and evaluate I...

a simple, sensitive and economically viable spectrophotometric method for the determination of corticosteroids (predinsolone {psl}, dexamethasone {dex}, prednisone {ps}, betamethasone sodium phosphate {bep} and hydrocortisone {hyd} has been developed. the method involves the oxidation of corticosteroids by iron (iii) and subsequent complexation of iron (ii) with potassium hexacynoferrate (iii),...

The aerodynamic diameter of pharmaceutical aerosols is the main factor governing their deposition in the human respiratory tract. Particle size of the pharmaceutical aerosols is characterized by liquid impingers and Andersen Cascade Impactors. The present study was aimed at comparing two metered dose inhaler formulation containing formoterol fumarate (6 μg) and budesonide (200 μg). These two fo...