Department of Physiology and Pharmacology (S.J.H.), Medical School, Queen’s Medical Centre, Nottingham, England; Department of Chemistry (C.R.G.), University College London, Christopher Ingold Laboratories, London, England; Department of Pharmacochemistry (H.T.), Leiden/Amsterdam Center for Drug Research, Vrije Universiteit, Amsterdam, The Netherlands; Unité de Neurobiologie (J.C.S.), Paris, Fr...

This study investigated the changes of plasma absorbed components in rats after oral administration hederagenin. Serum pharmacochemistry analysis hederagenin was carried out to understand its metabolic body. Biological samples were collected and then migration hederagenin-containing serum established by UPLC/Q-TOF-MS technique. Possible metabolites obtained for comprehensive through relevant st...

background : the aim of this study was to evaluate the antimalarial effects of iranian flora artemisia khorassanica against plasmodium berghei in vivo and pharmacochemistry of its natural components. methods : the aerial parts of iranian flora a. khorasanica were collected at flowering stage from khorassan province, northeastern iran in 2008. they were air-dried at room temperature; powder was ...

Our Journal, now in its third year, has earned for itself a reputation of being the fastest forum for disseminating the results of research on inflammation processes, in particular within the field of mediators. This field continues to undergo a spectacular growth in several directions (immunopathology, allergology, joint conditions, pulmonary disorders, transplantation etc.), all of which are ...

Within the framework of our attempts to synthesize pleiotropic anti-inflammatory agents, we have synthesized some chalcones and their corresponding 3,4-pyrrolyl derivatives. Chalcones constitute a class of compounds with high biological impact. They are known for a number of biological activities, including anti-inflammatory and free radical scavenging activities. They inhibit several enzymes i...

The aim of the present study was to identify absorbed components raw fuzi in a rat adjuvant arthritis model and evaluate therapeutic effects three alkaloids fuzi’s components, aconitine, hypaconitine mesaconitine. established by complete Freund’s injection Wistar rats. Then animal’s body weight, condition fur, hind paw volume immunological parameters, nitric oxide tumor necrosis factor-alpha, w...