objective: to evaluate the effect of niprd-am1 on cyp3a4 in order to generate clinically significant data for its safe and efficacious use. materials and methods: niprd-am1 is a phytomedicine developed from aqueous root extracts of nauclea latifolia smith (rubiaceae) for the treatment of uncomplicated malaria. the effect of niprd-am1 on cyp3a4 was measured with and without the addition of niprd...

Background: Reciprocal drug interactions are among the most common causes of adverse drug reactions. We investigated the incidence and related risk factors associated with mutual drug interactions in relation to prescriptions written in the neurology wards of two major teaching hospitals in Shiraz, southern Iran. Methods: Data was collected from hand-written prescriptions on a daily basis. Mutu...

background : drug-drug interactions (ddis) are adverse reactions caused by a combination of drugs; they are often predictable and therefore avoidable or manageable. the objective of this study was to evaluate the nature, type and prevalence of potential ddis in prescriptions dispensed in university-based community pharmacies in tehran, iran. methods: from july 2012 to february 2014, sample of 1...

drug-drug interactions (ddis) can lead to increased toxicity or reduction in therapeutic efficacy. this study was designed to assess the incidence of potential drug interactions (pdi) and rank their clinical value in post coronary care unit (post-ccu) of a teaching hospital in tehran, iran.in this prospective study, three pharmacists with supervision of a clinical pharmacist actively gathered n...

background:     purpose:     methods:     results     conclusion     rug interactions , active training : drug interactions are common medical errors in gorgan province and training can decrease their rate. keywords. d   : overall prevalence of drug interactions was 8.93%, of which 6.55% were major, 65.58% moderate and 27.87% minor. interactions were mostly seen among male doctors. the physicia...

Drug-drug interaction (DDI) is one of the most important problems in the treatment of patients suffering from different chronic intractable diseases. The war-injured veterans are one of the groups that are prone to chronic refractory diseases. This investigation was conducted on war-injured veterans treated in a multi-disciplinary clinic in Tehran. Using Poisson model, a total of 150 patients w...

drug prescription errors are a common cause of adverse incidents and may lead to adverse outcomes, sometimes in subtle ways, being compounded by circumstances or further errors. therefore, it is important that veterinarians issue the correct drug at the correct dose. using two or more prescribed drugs may lead to drug interactions. some drug interactions are very harmful and may have potential ...