نتایج جستجو برای: pharmacokinetic studies
تعداد نتایج: 1444479 فیلتر نتایج به سال:
A rapid, sensitive and reproducible HPLC method using amperometric detector was developed and validated for the analysis of clarithromycin in human plasma. The separation was achieved on a monolithic silica column (MZ- C8 125×4.0 mm) using acetonitrile- methanol-potassium dihydrogen phosphate buffer (40:6:54,v/v), with pH of 7.5, as the mobile phase at a flow rate of 1.5 mL/min. The assay enabl...
organophosphate (op) poisoning is one of the most common causes of poisoning in developing countries especially in southeastern asia. poisoning with phosphorus-containing organic chemicals or op compounds can be managed with antidotes like oximes which are potential reactivators of acetylcholinesterase (ache). the efficacy of oxime therapy in op poisoned patients mainly depends upon various fac...
BACKGROUND AND OBJECTIVES Oral enzalutamide (160 mg once daily) is approved for the treatment of metastatic castration-resistant prostate cancer (mCRPC). This article describes the pharmacokinetics of enzalutamide and its active metabolite N-desmethyl enzalutamide. METHODS Results are reported from five clinical studies. RESULTS In a dose-escalation study (n = 140), enzalutamide half-life w...
A rapid, sensitive and reproducible HPLC method using amperometric detector was developed and validated for the analysis of clarithromycin in human plasma. The separation was achieved on a monolithic silica column (MZ- C8 125×4.0 mm) using acetonitrile- methanol-potassium dihydrogen phosphate buffer (40:6:54,v/v), with pH of 7.5, as the mobile phase at a flow rate of 1.5 mL/min. The assay enabl...
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