Among all newly discovered chemical entities about 40% drugs are lipophillic and fail to reach market due to their poor water solubility. Drug with poor water solubility cause slow dissolution rates, generally show erratic and incomplete absorption leading to low bioavailability when administered orally. Aqueous solubility of any therapeutically active substance is a key property, as it governs...

Physicochemical properties of surimi and kamaboko obtained of solubility in acid, alkaline and conventional methods were compared. The results indicated that the highest protein recovery was related to solubility in acid, alkaline and conventional methods, respectively. The highest removal of lipid and myoglobin was observed by solubility in alkali. Excretion of total pigment and sulfhydryl gro...

using the evaporating method, the solubility of potassium nitrate was determined in various mixtures containing water and ethanol at 25°c. the results show that the solubility of kno3 decreases with increasing the mass percent of ethanol in the mixtures. this trend is along with decreasing the dielectric constant of water+ethanol mixtures. moreover, it can be concluded that the totqal solubilit...

introduction: solubility of mineral trioxide aggregate (mta) is an important characteristic that affects other properties such as microleakage and biocompatibility. distilled water (dw) has previously been used for solubility tests. this experimental study compared the solubility of mta in dw, synthetic tissue fluid (stf) and new simulated plasma (sp). methods and materials: in this study, 36 s...

objective: application of chemical solvents especially in problematic canals is usually a part of the retreatment process.this study was performed to compare the solubility of gutta- percha and resilon in chloroform and to find the effect of sample thickness as well as the time of shaking on their solubility. materials and methods: specific weight of resilon and gutta-percha was placed in a sam...

       The Extended Hildebrand Solubility Parameter Approach (EHSA) is used to estimate the solubility of satranidazole in binary solvent systems. The solubility of satranidazole in various water-PEG 400 mixtures was analyzed in terms of solute-solvent interactions using a modified version of Hildebrand-Scatchard treatment for regular solutions. The solubility equation employs term interaction ...

objective: the purpose of this study was to evaluate the solubility of three luting cements in artificial saliva. materials and methods: twenty disks (10×4 mm) of polycarboxylate, zinc phosphate and glass ionomer cements were prepared according to manufactures’ instructions. after setting, they were desiccated and each ten specimens were immersed in artificial saliva with special ph (3 or 5), c...

the solubility of naproxen in binary mixtures of polyethylene glycol 200 (peg 200) + water at the temperature range from 298.0 k to 318.0 k were reported. the combinations of jouyban-acree model + van’t hoff and jouyban-acree model + partial solubility parameters were used to predict the solubility of naproxen in peg 200 + water mixtures at different temperatures. combination of jouyban-acree m...

• The Body's Need for Vitamins and Minerals in the Diet • Molecular Basis for Water Solubility and Fat Solubility (e.g., of Vitamins) Polarity of Solvent and Solute Thermodynamics of Dissolution • Structures and Functions of Key Vitamins • Effect of Olestra (Artificial Fat) on Vitamin Solubility • Quantitative Measures of Mineral Solubility Solubility Product (Ksp) Solubility (S) • Calcium in t...