Five 2-(2-phenylethyl)chromones including a new one, (5S,6R,7S,8R)-5,8-dichloro-6,7-dihydroxy-2-phenylethyl-5,6,7,8-tetrahydro-4H-chromen-4-one (1), and four known ones (2-5), were isolated from 150 mM NaCl-elicited Aquilaria sinensis cell suspension cultures. In addition, three feruloyl amides (6-8), six nucleosides (9-14), (+)-syringaresinol (15), indole-3-carboxaldehyde (16), and two glycosi...

The resinous wood of Aquilaria sinensis, known as agarwood (Chen Xiang in Chinese), is traditionally used for the treatment of abdominal pain, vomiting, circulatory disorders, and dyspnea. Four new 2-(2-phenylethyl)-4H-chromen-4-one derivatives, namely 7-methoxy-2-[2-(4'-hydroxy-phenyl)ethyl]chromone (1), 7-hydroxy-2-[2-(4'-methoxyphenyl)ethyl]chromone (2), 5,6-dihydroxy- 2-[2-(3'-hydroxy-4'-me...

6-Phenylethyl alcohol and 6-phenylethyl acetate have rose-like flavors and are yery important aroma components of higher boiling points in various alcoholic beverages, 6Phenylethyl alcohol exists in fairly large quantity in various alcoholic beverages, e.g., 40-60 ppm in sake, 1O-I5 ppm in whisky, 15-20 ppm in beer, 5-6 ppm in brandy, and 30-40 ppm in shouchu,i) We expected that the increase of

The chiral carbene bis[bis(R-1-phenylethyl)amino]cyclopropenylidene 2 and its dicarbene-silver complex [Ag(2)2]BF4 (3) have been isolated in good yields from the reactions of bis[bis(R-1-phenylethyl)amino]cyclopropenylium tetrafluoroborate (1)BF4 with potassium bis(trimethylsilyl)amide or with Ag2O, respectively; the molecular structures of (1)ClO4, 2 and 3 have been determined by X-ray diffrac...

Allergic contact dermatitis caused by phenylethyl resorcinol [4-(1-phenylethyl)-1,3-benzenediol], a skin-lightening agent in cosmetics Michi Gohara1,2, Akiko Yagami1, Kayoko Suzuki3, Yusuke Morita1, Akiyo Sano1, Yohei Iwata1, Takashi Hashimoto2 and Kayoko Matsunaga1 1Department of Dermatology, Fujita Health University School of Medicine, Aichi, 470-1192, Japan, 2Department of Dermatology, Kurum...

A series of new 3,5-disubstituted-tetrahydro-2H-1,3,5-thiadiazine-2-thione (THTT) derivatives (4a-g) were prepared using a convenient and general one-pot procedure and evaluated for their in vitro antibacterial and antifungal activities by using the microdilution method in comparison with ampicillin and fluconazole. 3-Phenyl-5-(1-phenylethyl)-tetrahydro-2H-1,3,5-thiadiazine-2-thione (4a) and 3p...

A total of fifty-six chromones, including seven 5,6,7,8-tetrahydro-2-(2-phenylethyl)-chromones (THPECs), five 5,6-epoxy-2-(2-phenylethyl)chromones (EPECs), seven 5,6:7,8-diepoxy-2-(2-phenylethyl)chromones (DEPECs) and thirty-seven 2-(2-phenylethyl)chromones of the flidersia type (FTPECs), were characterized by HPLC/DAD/ESI/MS/MS in three agarwood samples (from Aquilaria crassna) induced by arti...

Incorporation of amino acids into proteins in HeLa cells, virus-transformed 3T3 mouse fibroblasts, and mouse plasmacytoma cells is inhibited after the addition of L-1-tosylamido-2-phenylethyl chloromethyl ketone, an alkylating agent and chymotrypsin-specific protease inhibitor. Addition of this drug to tissue culture cells at concentrations of 20 to 30 mug per ml results in an irreversible inhi...

The effect of canola (Brassica napus) as a crop suppressive to Pratylenchus neglectus is in part due to the release of nematicidal isothiocyanates, particularly 2-phenylethyl isothiocyanate, from degrading root tissues. However, many cultivars of canola are relatively susceptible to P. neglectus and will fail to reduce soil populations of the nematode. A survey of B. napus accessions and closel...

BACKGROUND The antidepressant amitriptyline is commonly used orally for the treatment of chronic pain, particularly neuropathic pain, which is thought to be caused by high-frequency ectopic discharge. Among its many properties, amitriptyline is a potent Na(+) channel blocker in vitro, has local anesthetic properties in vivo, and confers additional blockade at high stimulus-discharge rates (use-...