Phytoestrogens are naturally occurring estrogenic compounds found in plants and plant products. These compounds are also known to exert cellular effects independent of their interactions with estrogen receptors. We studied the effects of the phytoestrogens phloretin, phloridzin, genistein, and biochanin A on Ca(2+) uptake into the cardiac muscle sarcoplasmic reticulum (SR). Genistein and biocha...

Novel derivatives of the apple-derived flavonoid phloridzin have been found to be potent antioxidants in vitro [I] . The antioxidant action of oestrogens such as 17 P-oestradiol may contribute to their cardioprotective effects [2]. Phloretin the aglycone form of phloridzin has been reported to be oestrogenic [3] and its 3-hydroxy derivative may have enhanced weak oestrogen activity that could e...

The phenolic compound phloridzin (phloretin 2′-O-glucoside, variously named phlorizin, phlorrhizin, phlorhizin or phlorizoside) is a prominent member of the chemical class of dihydrochalcones, which are phenylpropanoids. Phloridzin is specifically found in apple and apple juice and known for its biological properties. In particular we were attracted by potential dermo-cosmetic application...

In insulin-deprived alloxan-induced diabetic dogs with severe hyperglycemia and marked hyperglucagonemia, glucagon was not suppressed by intravenous infusion of glucose at a progressively increasing rate up to 24 mg/kg of body weight per min. However, when the hyperglycemia was corrected by phloridzin, a blocker of renal tubular glucose reabsorption, the hyperglucagonemia was readily suppressed...

MARCHEV, A., I. IVANOV, R. VRANCHEVA and A. PAVLOV, 2013. Solid phase extraction and HPLC determination of phloridzin in natural products. Bulg. J. Agric. Sci., Supplement 2, 19: 201–203 A reliable technique for routine analysis of phloridzin from natural products (apples and plums) combining solid phase extraction with Amberlite XAD4 and subsequent HPLC analysis was developed. The proposed met...

The antioxidant properties of two apple dihydrochalcones, namely phloretin and phloridzin, were evaluated and compared with those of alpha-tocopherol and butylated hydroxytoluene (BHT). The effects were studied in an oil-in-water emulsion system containing methyl linolenate (ML), methyl eicosapentaenoate (MEPA), and methyl docosahexaenoate (MDHA) in which oxidation was initiated by the peroxyl ...