It has been demonstrated in animal studies that polyunsaturated fatty acids (PUFA) prevent ischemia-induced malignant ventricular arrhythmias, a major cause of sudden cardiac death in humans. To learn how these PUFA, at low micromolar concentrations, exert their antiarrhythmic activity, we studied their effects in vitro on the contractions of isolated cardiac myocytes and the conductances of th...

Acta Medica Indonesiana, today is The Indonesian Journal of Internal Medicine, addresses all the concerns of science on Internal Medicine. In this edition, we publish a study conducted by Putra ST.1, a cohort retrospective study on teenager subjects who were breast-fed as infants and the effects on the development of atherosclerosis. This study supported the idea that breastfeeding may have pro...

The identification of the genes responsible for various genetic liver disorders lead to a better understanding of basic physiology of hepatic transport systems. In this review we focus on transport systems involved in the generation of bile and in the maintenance of copper homeostasis. Abnormal function of these transporters results in diseases like Wilson’s disease, progressive familial choles...