نتایج جستجو برای: pht model

تعداد نتایج: 2104935  

Journal: :Infection and immunity 2013
Charles D Plumptre Abiodun D Ogunniyi James C Paton

Streptococcus pneumoniae is a major human pathogen responsible for massive global morbidity and mortality. The pneumococcus attaches a variety of proteins to its cell surface, many of which contribute to virulence; one such family are the polyhistidine triad (Pht) proteins PhtA, PhtB, PhtD, and PhtE. In this study, we have examined the mechanism of Pht surface attachment using PhtD as a model. ...

Journal: :British journal of rheumatology 1996
E T Koh P Lee D D Gladman M Abu-Shakra

A retrospective chart review was carried out on 344 patients with systemic sclerosis (SSc) followed prospectively for the occurrence of pulmonary hypertension (PHT). Seventeen patients (4.9%) were found to have PHT. Eight patients had isolated PHT, while in nine PHT was associated with restrictive lung disease (RLD). The subset with RLD developed PHT earlier, but had longer survival than patien...

2010
M. Ibarra Marta Vázquez A. Canale

Objective: To assess the reliability of salivary phenytoin (PHT) concentrations and predicted free PHT levels by Sheiner-Tozer equation in order to substitute measured free PHT concentrations in critically ill patients. Methodology: Twenty-four neurocritically ill adult patients receiving intravenous PHT were included in the study. Analyses of total, free plasma and saliva PHT concentrations we...

Journal: :African journal of traditional, complementary, and alternative medicines : AJTCAM 2008
Agbaje Esther Oluwatoyin Adeneye Adejuwon Adewale Adeleke Tijani Isaac

The study investigated the anti-nociceptive and anti-inflammatory properties of a Nigerian Polyherbal Health Tonic tea aqueous extract (PHT) in rodents of both sexes. 100-500 mg kg(-1) of the aqueous extract was administered via the intra-peritoneal (i.p.) and oral (p.o.) routes to 5 groups of mice using tail immersion, tail clip, formalin and acetic acid-induced writhing tests of experimental ...

Journal: :Stroke 2005
Andrew M Naidech Kurt T Kreiter Nazli Janjua Noeleen Ostapkovich Augusto Parra Christopher Commichau E Sander Connolly Stephan A Mayer Brian-Fred M Fitzsimmons

BACKGROUND AND PURPOSE Phenytoin (PHT) is routinely used for seizure prophylaxis after subarachnoid hemorrhage (SAH), but may adversely affect neurologic and cognitive recovery. METHODS We studied 527 SAH patients and calculated a "PHT burden" for each by multiplying the average serum level of PHT by the time in days between the first and last measurements, up to a maximum of 14 days from ict...

Journal: :Journal of neurophysiology 2016
Zhen Zeng Elisa L Hill-Yardin David Williams Terence O'Brien Andris Serelis Christopher R French

The antiepileptic drug phenytoin (PHT) is thought to reduce the excitability of neural tissue by stabilizing sodium channels (NaV) in inactivated states. It has been suggested the fast-inactivated state (IF) is the main target, although slow inactivation (IS) has also been implicated. Other studies on local anesthetics with similar effects on sodium channels have implicated the NaV voltage sens...

2014
MASAKI ONOYAMA KAZUO AZUMA TAKESHI TSUKA TOMOHIRO IMAGAWA TOMOHIRO OSAKI SABURO MINAMI NOBUHIKO OGAWA YOSHIHARU OKAMOTO

The present study used indocyanine green (ICG) and a broadband light source apparatus [photodynamic hyperthermal therapy (PHT) group] in order to treat a colon 26 tumor-bearing mouse model. The other groups were administered either ICG alone (ICG group), light alone (light group) or no treatment (control group). Following the treatment, tumor growth was measured. Nine days after the treatment, ...

Journal: :American journal of physiology. Heart and circulatory physiology 2005
Julien Boissiere Mathieu Gautier Marie-Christine Machet Gilles Hanton Pierre Bonnet Veronique Eder

We aimed to assess the accuracy of Doppler tissue imaging (DTI) in detecting right ventricle (RV) dysfunction and electromechanical coupling alteration following pulmonary hypertension (PHT) in rat. PHT was induced by chronic hypoxia exposure (hypoxic PHT) or monocrotaline treatment (monocrotaline PHT). In both PHT models, we observed transparietal RV pressure increase and remodeling, including...

2018
Mohammad Asif

Fosphenytoin, the disodium phosphate ester of 3‒ hydroxymethyl‒5,5‒diphenylhydantoin (FPHT/ACC 9653/Cerebyx), phosphate ester pro‒drug of phenytoin, 5,5‒diphenylhydantoin (PHT/ Dilantin), was developed to overcome complications associated with parenteral PHT administration in treatment of seizures, short‒term prophylaxis and treatment of repetitive or prolonged seizures and status epilepticus (...

2014
Yutaka Negoro Takashi Higashi Hiroaki Matsuoka Kyohei Watanabe Toshiaki Igarashi Yuichiro Kayano Ryoichi Yano Toshiaki Nakamura Mikio Masada

Although combination therapy with the oral fluoropyrimidine anticancer drug S-1 and the anticonvulsant phenytoin (PHT) is known to increase blood levels of PHT and the risk of intoxication, reports on long-term monitoring of blood levels of PHT during combined S-1 and PHT treatment and a thorough understanding of their interaction are lacking. This report aims to describe interactive effects of...

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