Six withanolides (1-6), as well as two known withanolides (physachenolide D 7 and withanoside VI 8), were isolated from the aerial parts of Physalis coztomatl (Solanaceae). Structural elucidations of 1-6 were achieved through 2D NMR and other spectroscopic techniques, while the structure of 1 was confirmed by X-ray crystallographic analysis. In addition, the stereochemical orientation of the 17...

BACKGROUND Despite development of current targeted therapies for medullary thyroid cancer (MTC), long-term survival remains unchanged. Recently isolated novel withanolide compounds from Solanaceae physalis are highly potent against MTCs. We hypothesize that these withanolides uniquely inhibit RET phosphorylation and the mammalian target of rapamycin (mTOR) pathway in MTC cells as a mechanism of...

We developed a HPLC/MS method for the identification and determination of solanine in plants. This method was applied for samples of Solanum dulcamara (from Iaşi and Vânători Neamţ areas in Romania) and Physalis alkekengi (from Bucium and Breazu, Iaşi, Romania) during August-September 2009. Isolation of solanine was performed by extraction with a mixture consisting of water/methanol/acetic acid...

The paper presents the results of the qualitative and quantitative determination of scopoletin (SLT) in Physalis alkekengi and Solanum dulcamara (Solanaceae) by highperformance liquid chromatography tandem mass spectrometry (HPLC/MS). The plant samples were harvested around Iasi on July 2007, July 2008, August-September 2009. Scopoletin was extracted from dried leaves by two methods: with metha...

Background: Determining the sperm quality can be measured by calculating motility and spermmotility is governed intracellular calcium (Ca2+) concentration. However, calciumincrease found in essential hypertension cases may decrease acrosome reaction increase ROS production,and trigger cell apoptosis. Ground cherry (Physalis angulata L) an herbal plant containingbioflavonoid as antioxidant which...