The yeast strains that are resistant to high concentration of ethanol have biotechnological benefits and aresuitable models for physiology and molecular genetics research fields. A novel ethanol-tolerant mutant strain,mut1, derived from the commercial Saccharomyces cerevisiae showed higher ethanol production, and alsodemonstrated resistance to ethanol but not to other alcohols...

background coronary artery diseases (cad) are associated with psychological problems such as anxiety and depression in patients. thus, management of these problems can consider as an important intervention by health care workers, especially nurses. objectives the purpose of this study was to investigate the effectiveness of patient-focused clinical pathway on anxiety, depression and satisfactio...

objective(s):intermittent hypoxia (ih), caused by obstructive sleep apnea (osa), could cause hippocampus or neuron damage through multiple signaling pathways, while the underlying mechanisms are still unclear. thus, the present study aimed to explore the effect of ih on the biological functions of microglia cells. materials and methods:cell proliferation of bv2 cells after exposure to ih were o...

The activation of signal transducer and activator of transcription (STAT) family genes, especially STAT5 and STAT3, has been established in multiple solid tumors and hematological malignancies. Recently we discovered somatic activating STAT3 mutations in 40% of T-cell large granular lymphocytic (LGL) leukemia and 30% of NK-cell LGL leukemia patients (Koskela, Eldfors et al. NEJM, 2012, 17;366(2...

We described recently the activation of the Janus kinasesignal transducer and activator of transcription (JakSTAT) and mitogen-activated protein (MAP) kinase pathways by leukemia inhibitory factor (LIF) through gp130, a signal transducer of IL-6-related cytokines, that transduces hypertrophic signals in cardiac myocytes. In addition, stimulation of gp130 by IL-6-related cytokines is known to ex...

The purpose of this study is to investigate the role of PI3K-Akt signaling in prostate cancer cell growth and androgen receptor (AR)-mediated gene expression. Androgendependent LNCaP cells and their androgen-independent counterpart, LNCaP-AI cells, were used. We found that PI3KAkt signaling is elevated in LNCaP-AI cells compared to that in LNCaP cells and is involved in androgen-independent gro...

titanium dioxide is one kind of important materials, which has been extensively investigated because of its unique electronic and optical properties. a large number of efforts have been made to synthesize tio2 materials with different methods. in this review paper, we summarize the synthesis pathways, morphology, as well as crystallization of the nanostructured tio2. in addition, we also mentio...

it is clear that colorectal cancer (crc) develops through multiple genetic and epigenetic pathways. these pathways may be determined on the basis of three molecular features: (i) mutations in dna mismatch repair genes, leading to a dna microsatellite instability (msi) phenotype, (ii) mutations in apc and other genes that activate wnt pathway, characterized by chromosomal instability (cin) pheno...