S pinal cord injury (SCI) has been recognized as one of the conditions for which stem cell transplantation might fi rst prove benefi cial [1]. After SCI, loss of localized myelinating oligodendrocytes and grey matter neurons occurs, with glial scar formation and degeneration of both descending and ascending axons (Figure 1). Replacement of oligodendrocytes to promote remyelination or of neurons...

Correspondence to: Dr S Stacpoole Department of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK; [email protected] S pinal, also called neurogenic, claudication is common, and in the elderly it is almost invariably caused by degenerative disease of the lumbar spine. There are, however, a few rare but important other causes that should be co...

The objectives of the laboratory work reported here were to quantify the net rates of removal of manganese [Mn(II)] by streambed sediments collected from a metals contaminated, perennial stream system (Pinal Creek near Globe AZ) and to determine the key variable(s) responsible for the limited removal of Mn(II) observed at this field site. Pinal Creek is characterized by significant spatial grad...

Recent intensive samplings carried out across the mountainous regions of El Pinal (Puebla, Mexico) have provided new insights into the main environmental factors that affect the geographic distribution of the scarabaeinae beetles of the Trans-Mexican Volcanic Belt above 2500 m a.s.l. This study is part of an ongoing project investigating the diversity and biogeography of copro-necrophagous beet...

pinal cord stimulation (SCS) therapy enhances pain relief over a long-term period, decreases the need for opioid analgesics, improves quality of life, increases the rate of return to work, and manages pain economically. These benefi ts make SCS therapy a viable treatment option for seriously injured soldiers with complex regional pain syndrome (CRPS). The United States has recently been faced w...

The present manuscript describe simple, sensitive, rapid, accurate, precise and economical first derivative spectrophotometric method for the simultaneous determination of alfuzosin hydrochloride and finasteride in combined tablet dosage form. The derivative spectrophotometric method was based on the determination of both the drugs at their respective zero crossing point (ZCP). The first order ...

243 August 2013 S PINAL cord stimulation was first described in 1967 in an intriguing case report provided by Shealy et al.1 This first case involved the relief from cancerrelated pain using a surgically implanted electrode sutured to the dura to provide stimulation of the dorsal columns. Although the entire treatment was only for approximately 1 day before the patient’s demise, stimulation usi...

In life sciences, many technological problems have known solutions, but what prevents them from being practical is the lack of successful means of administration. Treatments for malnutrition and cancer are notable examples. The commonality between possible solutions for these two conditions is the need for a carrier that is capable of maintaining stable architecture while releasing what it enca...