The heterotrimeric complex between integrin-linked kinase (ILK), PINCH, and parvin is an essential signaling platform, serving as a convergence point for integrin and growth-factor signaling and regulating cell adhesion, spreading, and migration. We report a 1.6-A crystal structure of the ILK ankyrin repeat domain bound to the PINCH1 LIM1 domain, revealing the molecular basis of ILK-PINCH inter...

It is shown how the pinch technique algorithm may be consistently extended beyond the one-loop level to obtain the gauge-independent two-loop fermion self-energy −iΣ̂(p) in QCD in the pinch technique approach. The starting point for the construction is the general diagrammatic representation of the two-loop quark self-energy in terms of renormalized one-loop twoand three-point function and tree ...

The S-matrix pinch technique is used to derive an effective gluon selfenergy to one-loop order, when the theory is quantized in the Coulomb gauge (CG) and in the temporal axial gauge (TAG). When the pinch contributions are added, the gluon self-energies calculated in CG and TAG turn out to be identical and coincide with the result previously obtained with covariant gauges. The issue of gauge in...

For the first time, a geometry has been developed to allow for an axial imaging system for wire-array Z-pinch experiments that produce high-resolution x-ray images. The new geometry required a significant redesign of the electrode hardware. Calibrated areal density measurements of the Z-pinch plasma including wire cores, coronal plasma, streaming plasma, and the precursor were obtained. The sys...

This communication presents thermodynamic methodology for the performance evaluation of combustion gas turbine cogeneration system with reheat. The energetic and exergetic efficiencies have been defined. The effects of process steam pressure and pinch point temperature used in the design of heat recovery steam generator, and reheat on energetic and exergetic efficiencies have been investigated....

We study the power-law scaling behavior and pinch-off morphology of two-dimensional bubble rafts under tension. As a function of pulling speed, we observe two distinct pinch-off morphologies that have been observed in other fluid systems: long threads (LT) and double-cone (DC). At any given pulling speed, there is a nonzero probability of observing LT or DC, with the probability of observing LT...

The mathematics of gauge theories lies behind many of the most profound advances in physics in the past 200 years, from Maxwell's theory of electromagnetism to Einstein's theory of general relativity. More recently it has become clear that gauge theories also emerge in condensed matter, a prime example being the spin-ice materials which host an emergent electromagnetic gauge field. In spin-ice,...

To comprehend the sensorimotor control ability in diabetic hands, this study investigated the sensation, motor function and precision pinch performances derived from a pinch-holding-up activity (PHUA) test of the hands of diabetic patients and healthy subjects. The precision, sensitivity and specificity of the PHUA test in the measurements of diabetic patients were also analyzed. We hypothesize...

Dendrite sidebranch detachment is an important fragmentation mechanism during the solidification of alloys. The detachment occurs at the junction between a sidearm and its parent stem. While this pinching process is driven by capillarity, the presence of solidification opposes the instability. Using a simple numerical model of a single sidearm, we are able to capture the essential dynamics of d...